Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon.

Autor:	Nageeta F; Medicine, Ghulam Muhammad Mahar Medical College, Sukkur, PAK., Waqar F; Medicine, Allama Iqbal Medical College, Lahore, PAK., Allahi I; General Surgery, Allama Iqbal Medical College, Lahore, PAK., Murtaza F; Medicine, Allama Iqbal Medical College, Lahore, PAK., Nasir M; Medicine, RHC Dhonkal, Gujranwala, PAK., Danesh F; Internal Medicine, Liaquat University of Medical and Health Sciences, Thatta, PAK., Irshad B; Medicine, Sharif Medical and Dental College, Lahore, PAK., Kumar R; Spine Surgery, Sunnybrook Hospital, University of Toronto, Toronto, CAN., Tayyab A; Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK., Khan MSM; Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK., Kumar S; Medicine and Surgery, Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, PAK., Varrassi G; Pain Medicine, Paolo Procacci Foundation, Rome, ITA., Khatri M; Medicine and Surgery, Dow University of Health Sciences, Karachi, PAK., Muzammil MA; Internal Medicine, Dow University of Health Sciences, Karachi, PAK., Mohamad T; Cardiovascular Medicine, Wayne State University, Detroit, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Sep 19; Vol. 15 (9), pp. e45575. Date of Electronic Publication: 2023 Sep 19 (Print Publication: 2023).
DOI:	10.7759/cureus.45575
Abstrakt:	Diabetic kidney disease (DKD) is a significant complication of diabetes that requires innovative interventions to address its increasing impact. Precision medicine is a rapidly emerging paradigm that shows excellent promise in tailoring therapeutic strategies to the unique profiles of individual patients. This abstract examines the potential of precision medicine in managing DKD. It explores the genetic and molecular foundations, identifies biomarkers for risk assessment, provides insights into pharmacogenomics, and discusses targeted therapies. Integrating omics data and data analytics provides a comprehensive landscape for making informed decisions. The abstract highlights the difficulties encountered during the clinical implementation process, the ethical factors to be considered, and the importance of involving patients. In addition, it showcases case studies that demonstrate the effectiveness of precision-based interventions. As the field progresses, the abstract anticipates a future characterized by the integration of artificial intelligence in diagnostics and treatment. It highlights the significant impact that precision medicine can have in revolutionizing the provision of care for DKD. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Nageeta et al.)
Databáze:	MEDLINE
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