The effect of low- and moderate-intensity interval training on cognitive behaviors of male and female rats with VPA-induced autism.

Autor:	Sabet N; Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran., Abadi B; Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.; Brain Cancer Research Core (BCRC), Universal Scientific Education and Research Network (USERN), Kerman, Iran., Moslemizadeh A; Brain Cancer Research Core (BCRC), Universal Scientific Education and Research Network (USERN), Kerman, Iran., Rajizadeh MA; Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran., Arabzadeh F; Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Vakili Shahrbabaki SS; Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran., Soltani Z; Department of Biology, University of Turku, Turku 20014, Finland., Rafie F; Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.; Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Bashiri H; Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.; Visiting fellow Department of Medicine Division of Geriatrics and Gerontology Emory University School of Medicine.; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Oct 05; Vol. 9 (10), pp. e20641. Date of Electronic Publication: 2023 Oct 05 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e20641
Abstrakt:	Introduction: This study was performed to evaluate the effects of low and moderate treadmill exercise for one month on social interaction, anxiety-like behaviors, and spatial learning and memory in male and female autistic rats. Methods: Pregnant rats received valproic acid (VPA) (600 mg/kg/i.p) once on gestational day 12.5 to induce autism-like symptoms in the offspring. After delivery, the offspring were divided into six main groups, each with male and female subgroups: Control (CTL, prenatal normal saline), autism (prenatal VPA), low-intensity training (LIT,normal saline + low treadmill exercise), moderate -intensity training (MIT, normal saline + moderate treadmill exercise), VPA + LIT, and VPA + MIT. On the 60th day, the offspring were tested by the elevated plus maze (EPM), open field test (OFT), social interaction test (SIT), and Morris water maze (MWM). Results: The results showed that both LIT and MIT could partly alleviate anxiety-like behaviors induced by prenatal VPA exposure in two sexes. Social impairment was observed in the autistic rats and was improved by LIT in both sexes and MIT in females. No significant change was seen in the spatial learning and memory of autistic rats by exercise. Conclusion: The findings suggest that treadmill exercise can be helpful for improving some autism-like behaviors. Further studies are needed to investigate the involved mechanisms. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 Published by Elsevier Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu