The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye.

Autor:	Gül F; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, İstanbul, Türkiye., Kasapoğlu US; Clinic of Critical Care Medicine, Malatya Training and Research Hospital, Malatya, Türkiye., Sabaz MS; Clinic of Critical Care Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Türkiye., Ay P; Department of Public Health, Marmara University Faculty of Medicine, İstanbul, Türkiye., Oktay BD; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, İstanbul, Türkiye., Çalışkan G; Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Bursa Faculty of Medicine, Bursa, Türkiye., Demir N; Division of Critical Care Medicine, Clinic of Chest Diseases, University of Health Sciences Türkiye, Ankara City Hospital, Ankara, Türkiye., Sayan İ; Clinic of Critical Care Medicine, Sancaktepe Training and Research Hospital, İstanbul, Türkiye., Kabadayı F; Clinic of Critical Care Medicine, Sancaktepe Training and Research Hospital, İstanbul, Türkiye., Altuntaş G; Clinic of Critical Care Medicine, Elazığ City Hospital, Elazığ, Türkiye., Gümüş A; Clinic of Critical Care Medicine, Antalya Kepez State Hospital, Antalya, Türkiye., Kırca H; Clinic of Critical Care Medicine, Antalya Kepez State Hospital, Antalya, Türkiye., Şanlı D; Clinic of Critical Care Medicine, Batman Training and Research Hospital, Batman, Türkiye., Acil F; Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyabakır, Türkiye., Dedeoğlu A; Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyabakır, Türkiye., Ural SG; Clinic Critical Care Medicine, University of Health Sciences Türkiye, Erzurum City Hospital, Erzurum, Türkiye., Akın Şen İ; Clinic Critical Care Medicine, University of Health Sciences Türkiye, Erzurum City Hospital, Erzurum, Türkiye., Macit Aydın E; Division of Critical Care Medicine, Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye., Dayanır H; Division of Critical Care Medicine, Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye., Yelken B; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Türkiye., Ceylan İ; Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Bursa High Specialization Training and Research Hospital, Bursa, Türkiye., Aydın OÖ; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Türkiye., Eskidemir G; Clinic of Critical Care Medicine, Gaziosmanpaşa Training and Research Hospital, İstanbul, Türkiye., Aytekin A; Clinic of Anesthesiology and Reanimation, Göztepe Prof. Dr. Süleyman Yalçın City Hospital, İstanbul, Türkiye., Cengiz M; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Akdeniz University Faculty of Medicine, Antalya, Türkiye., Arslan Ü; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Akdeniz University Faculty of Medicine, Antalya, Türkiye., Akdağ D; Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Adana City Hospital, Adana, Türkiye., Alay GH; Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, İstanbul Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye., Tekin E; Clinic of Critical Care Medicine, Denizli State Hospital, Denizli, Türkiye., Yarar V; Clinic of Critical Care Medicine, Balıkesir Atatürk City Hospital, Balıkesir, Türkiye., Saracoğlu KT; Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Kartal Lütfi Kırdar Training and Research Hospital, İstanbul, Türkiye., Gök F; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Necmettin Erbakan University Faculty of Medicine, Konya, Türkiye., Alparslan V; Clinic of Critical Care Medicine, Hatay Training and Research Hospital, Hatay, Türkiye., Tuna V; Clinic of Critical Care Medicine, Adıyaman Training and Research Hospital, Adıyaman, Türkiye., Yıldız M; Clinic of Critical Care Medicine, Ağrı Training and Research Hospital, Ağrı, Türkiye., Şenoğlu N; Division of Critical Care Medicine, Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Tepecik Training and Research Hospital, İzmir, Türkiye., Kıraklı C; Department of Critical Care Medicine, University of Health Sciences Türkiye, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Türkiye., Yıldırım S; Department of Critical Care Medicine, University of Health Sciences Türkiye, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Türkiye., Saçar Kübüç K; Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Van Training and Research Hospital, Van, Türkiye., Erer A; Clinic of Critical Care Medicine, Tekirdağ İsmail Fehmi Cumalioğlu City Hospital, Tekirdag, Türkiye., Gültekin H; Clinic of Critical Care Medicine, Şırnak State Hospital, Şırnak, Türkiye., Özmen Süner K; Clinic of Critical Care Medicine, Sakarya Training and Research Hospital, Sakarya, Türkiye., Kuzgun Ö; Clinic of Critical Care Medicine, Sakarya Training and Research Hospital, Sakarya, Türkiye., Öztürk ÇE; Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Samsun Training and Research Hospital, Samsun, Türkiye., Karahan A; Clinic of Critical Care Medicine, Mersin City Hospital, Mersin, Türkiye., Deveci O; Clinic of Critical Care Medicine, Mersin City Hospital, Mersin, Türkiye., Ay M; Clinic of Anesthesiology and Reanimation, Antalya Training and Research Hospital, Antalya, Türkiye., Tüfek Öztan D; Clinic of Anesthesiology and Reanimation, Antalya Training and Research Hospital, Antalya, Türkiye., Akıncı SB; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, Türkiye., Yalçın Solak M; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, Türkiye., Bozbay S; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hitit University Faculty of Medicine, Çorum, Türkiye., Özçiftçi S; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hitit University Faculty of Medicine, Çorum, Türkiye., Gönderen K; Department of Critical Care Medicine, İzmir Katip Çelebi University, Atatürk Training and Research Hospital, İzmir, Türkiye., Küçük AO; Division of Critical Care Medicine, Department of Chest Diseases, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye., Uyan B; Department Critical Care Medicine, Gaziantep Şehit Kamil State Hospital, Gaziantep, Türkiye., Elay G; Division of Critical Care Medicine, Department of Internal Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye., Boyacı N; Division of Critical Care Medicine, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Türkiye., Timurkaan M; Clinic of Critical Care Medicine, Elazığ City Hospital, Elazığ, Türkiye., Karakoç E; Department of Critical Care Medicine, Çankırı State Hospital, Çankırı, Türkiye., Doğan L; Department of Critical Care Medicine, Altunizade Acıbadem Hospital, İstanbul, Türkiye., Yalçınkaya E; Department of Critical Care Medicine, Sivas Numune Hospital, Sivas, Türkiye., Kazancıoğlu L; Department of Anesthesiology and Reanimation, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Türkiye., Erdal Dönmez G; Department of Critical Care Medicine, University of Health Sciences Türkiye, İstanbul Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Türkiye., Yılmaz B; Department of Critical Care Medicine, University of Health Sciences Türkiye, İstanbul Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Türkiye., Ergül DF; Department of Critical Care Medicine, Amasya University Sabuncuoğlu Şerafettin Training and Research Hospital, Amasya, Türkiye., Boran M; Department of Critical Care Medicine, Amasya University Sabuncuoğlu Şerafettin Training and Research Hospital, Amasya, Türkiye., Özkarakaş H; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, İzmir Bozyaka Training and Research Hospital, İzmir, Türkiye., Karakaş B; Clinic of Critical Care Medicine, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Türkiye., Ergin Özcan P; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, İstanbul University Capa Faculty of Medicine, İstanbul, Türkiye., Anaklı İ; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, İstanbul University Capa Faculty of Medicine, İstanbul, Türkiye., Bayar MK; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Ankara University Faculty of Medicine, Ankara, Türkiye., Yüksel DY; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Ankara University Faculty of Medicine, Ankara, Türkiye., Akdağ Ş; Department of Anesthesiology and Reanimation, Yasar Eryılmaz Ağrı Doğubeyazıt State Hospital, Ağrı, Türkiye., Pişkin Ö; Department of Anesthesiology and Reanimation, Zonguldak Bülent Ecevit University Faculty of Medicine, Zonguldak, Türkiye., Temur S; Department of Anesthesiology and Reanimation, Yeditepe University Faculty of Medicine, İstanbul, Türkiye., Eyüpoğlu S; Clinic of Critical Care Medicine, Giresun Training and Research Hospital, Giresun, Türkiye., Tekir Yılmaz E; Clinic of Anesthesiology and Reanimation, Giresun University Faculty of Medicine, Giresun Training and Research Hospital, Giresun, Türkiye., Avcı GZ; Clinic of Anesthesiology and Reanimation, Giresun Prof. Dr. İlhan Özdemir State Hospital, Giresun Türkiye., Turan R; Clinic of Anesthesiology and Reanimation, Giresun Prof. Dr. İlhan Özdemir State Hospital, Giresun Türkiye., Alkan Bayburt F; Clinic of Anesthesiology and Reanimation, Giresun Prof. Dr. İlhan Özdemir State Hospital, Giresun Türkiye., Şahintürk H; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Başkent University Faculty of Medicine, Ankara, Türkiye., Güçyetmez B; Department of Anesthesiology and Reanimation, Acıbadem Mehmet Ali Aydınlar University Faculty of Medicine, İstanbul, Türkiye., Alparslan MM; Clinic of Anesthesiology and Reanimation, Aksaray University Training and Research Hospital, Aksaray, Türkiye., Yarıcı M; Department of Critical Care Medicine, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye., Yıldırım F; Department of Chest Diseases, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye., Yektaş A; Department of Anesthesiology and Reanimation, Siirt University Faculty of Medicine, Siirt, Türkiye., Yaman G; https://gucluyaman.com/tr/., Demirkıran O; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, İstanbul, Türkiye., Cinel İ; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, İstanbul, Türkiye.
Jazyk:	angličtina
Zdroj:	Balkan medical journal [Balkan Med J] 2023 Oct 20; Vol. 40 (6), pp. 435-444.
DOI:	10.4274/balkanmedj.galenos.2023.2023-6-90
Abstrakt:	Background: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear. Aims: To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19. Study Design: Multicenter prospective observational clinical study. Methods: This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated. Results: As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores ( p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) ( p = 0.004). Conclusion: Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients.
Databáze:	MEDLINE
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