A Pro-Metastatic Derivatives Eliminator for In Vivo Dual-Removal of Circulating Tumor Cells and Tumor-Derived Exosomes Impedes their Biodistribution into Distant Organs.

Autor: Sun Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China., Xing L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing, 210009, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, 210009, China., Luo J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China., Yu MT; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China., Wang XJ; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China., Wang Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China., Zhou TJ; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China., Jiang HL; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing, 210009, China.; Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, 210009, China.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Dec; Vol. 10 (34), pp. e2304287. Date of Electronic Publication: 2023 Oct 22.
DOI: 10.1002/advs.202304287
Abstrakt: Circulating tumor cells (CTCs) and tumor-derived exosomes (TDEs) play an irreplaceable role in the metastatic cascade and preventing them from reaching distant organs via blood circulation helps to reduce the probability of cancer recurrence and metastasis. However, technologies that can simultaneously prevent CTCs and TDEs from reaching distant organs have not been thoroughly developed until now. Here, inspired by hemoperfusion, a pro-metastatic derivative eliminator (PMDE) is developed for the removal of both CTCs and TDEs from the peripheral blood, which also inhibits their biodistribution in distant organs. This device is designed with a dual antibody-modified immunosorbent filled into a capture column that draws peripheral blood out of the body to flow through the column to specifically capture CTCs and TDEs, followed by retransfusing the purified blood into the body. The PMDE can efficiently remove CTCs and TDEs from the peripheral blood and has excellent biocompatibility. Interestingly, the PMDE device can significantly inhibit the biodistribution of CTCs and TDEs in the lung and liver by scavenging them. This work provides a new perspective on anti-metastatic therapy and has broad prospects in clinical applications to prevent metastasis and recurrence.
(© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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