Mental health outcomes in a population-based cohort of patients with prostate cancer.

Autor:	Hu S; Huntsman Cancer Institute, Salt Lake City, UT, USA.; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Chang CP; Huntsman Cancer Institute, Salt Lake City, UT, USA.; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Snyder J; Intermountain Healthcare, Salt Lake City, UT, USA., Deshmukh V; University of Utah Health Sciences Center, Salt Lake City, UT, USA., Newman M; University of Utah Health Sciences Center, Salt Lake City, UT, USA., Date A; Pedigree and Population Resource, Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT, USA., Galvao C; Pedigree and Population Resource, Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT, USA., Haaland B; Huntsman Cancer Institute, Salt Lake City, UT, USA.; Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA., Porucznik CA; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Gren LH; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Sanchez A; Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA., Lloyd S; Department of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, UT, USA., O'Neil B; Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA., Hashibe M; Huntsman Cancer Institute, Salt Lake City, UT, USA.; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Jazyk:	angličtina
Zdroj:	Journal of the National Cancer Institute [J Natl Cancer Inst] 2024 Mar 07; Vol. 116 (3), pp. 445-454.
DOI:	10.1093/jnci/djad175
Abstrakt:	Background: Few studies have evaluated mental health disorders comprehensively among patients with prostate cancer on long-term follow-up. The primary aim of our study was to assess the incidence of mental health disorders among patients with prostate cancer compared with a general population cohort. A secondary aim was to investigate potential risk factors for mental health disorders among patients with prostate cancer. Methods: Cohorts of 18 134 patients with prostate adenocarcinomas diagnosed between 2004 and 2017 and 73470 men without cancer matched on age, birth state, and follow-up time were identified. Mental health diagnoses were identified from electronic health records and statewide health-care facilities data. Cox proportional hazard models were used to estimate hazard ratios. All statistical tests were 2-sided. Results: The hazard ratios for mood disorders, including depression, among prostate cancer survivors increased for all follow-up periods compared with the general population. The hazard ratios for any mental illness increased with Hispanic, Black, or multiple races; people who were underweight or obese; those with advanced prostate cancer; and those undergoing their first course cancer treatment. We also observed statistically significantly increased hazard ratios for mental health disorders among patients with lower socioeconomic status (P < .0001) and increasing duration of androgen-deprivation therapy (P = .0348). Prostate cancer survivors had a 61% increased hazard ratio for death with a depression diagnosis. Conclusion: Prostate cancer diagnosis was associated with a higher risk of mental health disorders compared with the general population, which was observed as long as 10-16 years after cancer diagnosis. Providing long-term mental health support may be beneficial to increasing life expectancy for patients with prostate cancer. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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