Brown adipose tissue-derived metabolites and their role in regulating metabolism.

Autor: Ziqubu K; Department of Biochemistry, North-West University, Mmabatho 2745, South Africa., Dludla PV; Cochrane South Africa, South African Medical Research Council, Tygerberg 7505, South Africa; Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa., Mabhida SE; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg 7505, South Africa., Jack BU; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa., Keipert S; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden., Jastroch M; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden., Mazibuko-Mbeje SE; Department of Biochemistry, North-West University, Mmabatho 2745, South Africa. Electronic address: 36588296@nwu.ac.za.
Jazyk: angličtina
Zdroj: Metabolism: clinical and experimental [Metabolism] 2024 Jan; Vol. 150, pp. 155709. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.1016/j.metabol.2023.155709
Abstrakt: The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult humans have offered a new approach to treat obesity and metabolic diseases. Beyond its accomplished role in adaptive thermogenesis, BAT secretes signaling molecules known as "batokines", which are instrumental in regulating whole-body metabolism via autocrine, paracrine, and endocrine action. In addition to the intrinsic BAT metabolite-oxidizing activity, the endocrine functions of these molecules may help to explain the association between BAT activity and a healthy systemic metabolic profile. Herein, we review the evidence that underscores the significance of BAT-derived metabolites, especially highlighting their role in controlling physiological and metabolic processes involving thermogenesis, substrate metabolism, and other essential biological processes. The conversation extends to their capacity to enhance energy expenditure and mitigate features of obesity and its related metabolic complications. Thus, metabolites derived from BAT may provide new avenues for the discovery of metabolic health-promoting drugs with far-reaching impacts. This review aims to dissect the complexities of the secretory role of BAT in modulating local and systemic metabolism in metabolic health and disease.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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