Ceramides and their roles in programmed cell death.

Autor: Pilátová MB; Department of Pharmacology, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic., Solárová Z; Department of Pharmacology, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic., Mezencev R; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Solár P; Department of Medical Biology, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic. Electronic address: peter.solar@upjs.sk.
Jazyk: angličtina
Zdroj: Advances in medical sciences [Adv Med Sci] 2023 Sep; Vol. 68 (2), pp. 417-425. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.1016/j.advms.2023.10.004
Abstrakt: Programmed cell death plays a crucial role in maintaining the homeostasis and integrity of multicellular organisms, and its dysregulation contributes to the pathogenesis of many diseases. Programmed cell death is regulated by a range of macromolecules and low-molecular messengers, including ceramides. Endogenous ceramides have different functions, that are influenced by their localization and the presence of their target molecules. This article provides an overview of the current understanding of ceramides and their impact on various types of programmed cell death, including apoptosis, anoikis, macroautophagy and mitophagy, and necroptosis. Moreover, it highlights the emergence of dihydroceramides as a new class of bioactive sphingolipids and their downstream targets as well as their future roles in cancer cell growth, drug resistance and tumor metastasis.
Competing Interests: Declaration of competing interest The authors declare no conflict of interests.
(Copyright © 2023 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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