Viral pathogen detection using multiplex gastrointestinal molecular panels: The pros and cons of viral target inclusion.

Autor: Powell EA; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 234 Goodman St., Cincinnati, OH 45219, United States. Electronic address: powelleo@ucmail.uc.edu., Hata DJ; Department of Laboratory Medicine and Pathology, Mayo Clinic Florida, 4500 San Pablo Rd., Jacksonville, FL 32266, United States., Starolis MW; Quest Diagnostics, 14225 Newbrook Dr., Chantilly, VA 20155, United States.
Jazyk: angličtina
Zdroj: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2023 Dec; Vol. 169, pp. 105612. Date of Electronic Publication: 2023 Oct 15.
DOI: 10.1016/j.jcv.2023.105612
Abstrakt: Diagnosis of gastrointestinal infections has been revolutionized by the development of in vitro diagnostic (IVD) multiplex molecular panels for the detection of viral nucleic acids. In addition to a high degree of accuracy, these panels are commercially available and relatively simple to perform in the clinical laboratory. However, use of these panels must be carefully considered owing to the laboratory costs of the test, limited reimbursement, and potential for overuse. In this review from the Pan American Society for Clinical Virology, we focus on the viral components of GI multiplex panels (GIPs), presenting a brief overview of pathogens included on most panels and a discussion of advantages and challenges of the inclusion of viral targets on GIPs that should be considered before implementation in the clinical laboratory.
Competing Interests: Declaration of Competing Interest D. Jane Hata and Eleanor Powell report no financial conflicts of interest. M. Starolis is a full-time employee and stockholder at Quest Diagnostics and has served as an unpaid advisor to Roche and BioRad. D. Jane Hata, Eleanor Powell, and M. Starolis are all members of the Pan American Society for Clinical Virology Clinical Practice and Public Policy Committee.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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