Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV ± cancer.

Autor: Ayuso JM; Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. ayusodomingu@wisc.edu.; Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. ayusodomingu@wisc.edu.; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. ayusodomingu@wisc.edu., Farooqui M; Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Virumbrales-Muñoz M; Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Denecke K; Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Rehman S; Morgridge Institute for Research, 330 N Orchard street, Madison, WI, USA., Schmitz R; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Morgridge Institute for Research, 330 N Orchard street, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA., Guerrero JF; McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, USA.; Institute for Molecular Virology, University of Wisconsin, Madison, WI, USA., Sanchez-de-Diego C; Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Campo SA; Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Maly EM; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Morgridge Institute for Research, 330 N Orchard street, Madison, WI, USA., Forsberg MH; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, USA., Kerr SC; Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Striker R; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, USA.; Vivent Health, Milwaukee, USA., Sherer NM; McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, USA.; Institute for Molecular Virology, University of Wisconsin, Madison, WI, USA., Harari PM; Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Capitini CM; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, USA., Skala MC; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Morgridge Institute for Research, 330 N Orchard street, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA., Beebe DJ; Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Oct 21; Vol. 14 (1), pp. 6681. Date of Electronic Publication: 2023 Oct 21.
DOI: 10.1038/s41467-023-41625-8
Abstrakt: Numerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous factors that dampen the immune response, including viruses like human immunodeficiency virus. In this study, we leverage human-derived microphysiological models to reverse-engineer the HIV-immune system interaction and evaluate the potential of memory-like natural killer cells for HIV + head and neck cancer, one of the most common tumors in patients living with human immunodeficiency virus. Here, we evaluate multiple aspects of the memory-like natural killer cell response in human-derived bioengineered environments, including immune cell extravasation, tumor penetration, tumor killing, T cell dependence, virus suppression, and compatibility with retroviral medication. Overall, these results suggest that memory-like natural killer cells are capable of operating without T cell assistance and could simultaneously destroy head and neck cancer cells as well as reduce viral latency.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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