The effect of oral dexamethasone on duration of analgesia after upper limb surgery under infraclavicular brachial plexus block: a randomised controlled trial.

Autor: Maagaard M; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark., Plambech MZ; Department of Anaesthesiology, Naestved, Slagelse and Ringsted Hospitals, Slagelse, Denmark., Funder KS; Department of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Denmark., Schou NK; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark., Mølgaard AK; Department of Anaesthesiology, Naestved, Slagelse and Ringsted Hospitals, Slagelse, Denmark., Stormholt ER; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark., Leth MF; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark., Bukhari S; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark., Mortensen A; Department of Anaesthesiology, Naestved, Slagelse and Ringsted Hospitals, Slagelse, Denmark., Lunn TH; Department of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Denmark., Tryggedsson I; Department of Orthopaedic Surgery and Traumatology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Denmark., Nørskov AK; Department of Anaesthesiology, Copenhagen University Hospital, North Zealand Hospital, Hillerød, Denmark., Zamany C; Department of Orthopaedic Surgery, Trauma Unit, Zealand University Hospital, Køge, Denmark., Toquer P; Department of Orthopaedic Surgery, Trauma Unit, Zealand University Hospital, Køge, Denmark., Jaeger P; Department of Anaesthesia, The Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Andersen JH; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark., Mathiesen O; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.
Jazyk: angličtina
Zdroj: Anaesthesia [Anaesthesia] 2023 Dec; Vol. 78 (12), pp. 1465-1471. Date of Electronic Publication: 2023 Oct 21.
DOI: 10.1111/anae.16149
Abstrakt: The effects of oral dexamethasone on peripheral nerve blocks have not been investigated. We randomly allocated adults scheduled for forearm or hand surgery to oral placebo (n = 61), dexamethasone 12 mg (n = 61) or dexamethasone 24 mg (n = 57) about 45 min before lateral infraclavicular block. Mean (SD) time until first pain after block were: 841 (327) min; 1171 (318) min; and 1256 (395) min, respectively. Mean (98.3%CI) differences in time until first postoperative pain for dexamethasone 24 mg vs. placebo and vs. dexamethasone 12 mg were: 412 (248-577) min, p < 0.001; and 85 (-78 to 249) min, p = 0.21, respectively. Mean (98.3%CI) difference in time until first postoperative pain for dexamethasone 12 mg vs. placebo was 330 (186-474) min, p < 0.001. Both 24 mg and 12 mg of oral dexamethasone increased the time until first postoperative pain compared with placebo in patients having upper limb surgery under infraclavicular brachial plexus block.
(© 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
Databáze: MEDLINE
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