The Effects of Crocus sativus (Saffron) on ADHD: A Systematic Review.

Autor:	Seyedi-Sahebari S; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran., Farhang S; Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran., Araj-Khodaei M; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran., Akhondzadeh S; Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran., Naseri A; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.; Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran., Sanaie S; Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran., Frounchi N; Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
Jazyk:	angličtina
Zdroj:	Journal of attention disorders [J Atten Disord] 2024 Jan; Vol. 28 (1), pp. 14-24. Date of Electronic Publication: 2023 Oct 21.
DOI:	10.1177/10870547231203176
Abstrakt:	Background and Aim: Crocus sativus also known as saffron, is one of the most popular traditional plants. This study aims to evaluate the efficacy and safety of saffron extracts in ADHD. Method: This study includes clinical trial studies that assessed the efficacy and/or safety of saffron in ADHD patients. Non-English papers, review articles, commentaries, letters, observational studies, thesis, animal studies, in-vitro studies, and conference abstracts were not included. The risk of bias in randomized studies was evaluated based on the Cochrane RoB.2, and risk of bias in pre-post intervention studies was assessed using the ROBINS-I tool. Results: Four studies met our inclusion criteria with a total of 118 patients. The results manifested an efficient role of saffron as either an adjuvant therapy to MPH or a single therapy against ADHD, without significant safety issues. Discussion: Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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