Dynamic neural representations of memory and space during human ambulatory navigation.

Autor: Maoz SLL; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Medical Scientist Training Program, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA., Stangl M; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA., Topalovic U; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA., Batista D; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA., Hiller S; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA., Aghajan ZM; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA., Knowlton B; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Stern J; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Langevin JP; Neurosurgery Service, Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Fried I; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 69978, Israel., Eliashiv D; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Suthana N; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. nanthia@ucla.edu.; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA. nanthia@ucla.edu.; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. nanthia@ucla.edu.; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. nanthia@ucla.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Oct 20; Vol. 14 (1), pp. 6643. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.1038/s41467-023-42231-4
Abstrakt: Our ability to recall memories of personal experiences is an essential part of daily life. These episodic memories often involve movement through space and thus require continuous encoding of one's position relative to the surrounding environment. The medial temporal lobe (MTL) is thought to be critically involved, based on studies in freely moving rodents and stationary humans. However, it remains unclear if and how the MTL represents both space and memory especially during physical navigation, given challenges associated with deep brain recordings in humans during movement. We recorded intracranial electroencephalographic (iEEG) activity while participants completed an ambulatory spatial memory task within an immersive virtual reality environment. MTL theta activity was modulated by successful memory retrieval or spatial positions within the environment, depending on dynamically changing behavioral goals. Altogether, these results demonstrate how human MTL oscillations can represent both memory and space in a temporally flexible manner during freely moving navigation.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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