The latest model has just arrived! A new experimental mouse model of PLA2R1-associated membranous nephropathy.
| Autor: | Beck LH Jr; Nephrology Section, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, USA. Electronic address: laurence.beck@bmc.org. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Kidney international [Kidney Int] 2023 Nov; Vol. 104 (5), pp. 878-880. |
| DOI: | 10.1016/j.kint.2023.09.003 |
| Abstrakt: | Much akin to the explosion in number of known target antigens in membranous nephropathy, there has been a rapid expansion in the availability of animal models involving the first 2 antigens discovered in adult disease, phospholipase A2 receptor and thrombospondin type 1 domain-containing 7A. In this issue, Tomas et al. describe a novel mouse model of phospholipase A2 receptor-associated membranous nephropathy that shows great promise for investigating molecular mechanisms of disease and as an experimental system for testing existing and emerging therapies. (Copyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|