Postresuscitation oxygen reserve index-guided oxygen titration in out-of-hospital cardiac arrest survivors: A randomised controlled trial.
| Autor: | Malinverni S; Emergency Department, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Rue Haute 322, 1000 Brussels, Belgium. Electronic address: stefano.malinverni@stpierre-bru.be., Wilmin S; Emergency Department, Centre Hospitalier Universitaire Brugmann, Avenue Jean Joseph Crocq 1, 1020 Bruxelles, Belgium., Stoll T; Emergency Department, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Rue Haute 322, 1000 Brussels, Belgium., de Longueville D; Emergency Department, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Rue Haute 322, 1000 Brussels, Belgium., Preseau T; Emergency Department, Centre Hospitalier Universitaire Brugmann, Avenue Jean Joseph Crocq 1, 1020 Bruxelles, Belgium., Mohler A; Emergency Department, Centre Hospitalier Universitaire Brugmann, Avenue Jean Joseph Crocq 1, 1020 Bruxelles, Belgium., Bouazza FZ; Emergency Department, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Rue Haute 322, 1000 Brussels, Belgium., Annoni F; Intensive Care Unit, Hôpital Erasme, Université Libre de Bruxelles, Route de Lennik 808, B-1070 Brussels, Belgium., Gerard L; Intensive Care Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Clos Chapelle-aux-Champs 43, 1200 Woluwe-Saint-Lambert, Brussels, Belgium., Denoel P; Emergency Department, Cliniques de l'Europe, Avenue De Fré 206, 1180 Uccle, Belgium., Boutrika I; Emergency Department, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Rue Haute 322, 1000 Brussels, Belgium. |
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| Jazyk: | angličtina |
| Zdroj: | Resuscitation [Resuscitation] 2024 Jan; Vol. 194, pp. 110005. Date of Electronic Publication: 2023 Oct 18. |
| DOI: | 10.1016/j.resuscitation.2023.110005 |
| Abstrakt: | Background and Purpose: Hyperoxia after return of spontaneous circulation is potentially harmful, and oxygen titration in a prehospital setting is challenging. This study aimed to compare outcomes of oxygen reserve index-supported prehospital oxygen titration during prehospital transport with those of standard oxygen titration. Methods and Trial Design: We enrolled patients who experienced return of spontaneous circulation after cardiac arrest in a prospective randomized study. Patients were randomly divided (1:1) to undergo oxygen titration based on the oxygen reserve index and SpO Results: A total of 92 patients were included in the study. The mean normoxia index was 0.828 in the control group and 0.847 in the intervention group (difference = 0.019 [95 % CI, -0.056-0.095]), with no significant difference between the groups. No significant differences were found in the incidence of hypoxia or hyperoxia between groups. No difference was found in the mean PaO Conclusion: Oxygen reserve index- combined with pulse oximetry-based prehospital oxygen titration did not significantly improve the normoxia index compared with standard oxygen titration based on pulse oximetry alone (NCT03653325). Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Stefano Malinverni received all the consumable necessary for the study from Masimo Corporation. All the other authors stated that they have no financial and personal relationships with other people or organizations that could inappropriately influence their work. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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