Vitamin B and One-Carbon Metabolite Profiles Show Divergent Associations with Cardiometabolic Risk Markers but not Cognitive Function in Older New Zealand Adults: A Secondary Analysis of the REACH Study.

Autor: Gillies NA; The Liggins Institute, The University of Auckland, New Zealand; The Riddet Institute, New Zealand., Milan AM; The Liggins Institute, The University of Auckland, New Zealand; The High-Value Nutrition National Science Challenge, New Zealand; AgResearch Ltd, Grasslands Research Centre, New Zealand., Cameron-Smith D; The Liggins Institute, The University of Auckland, New Zealand; The Riddet Institute, New Zealand; School of Agriculture, Food and Ecosystem Sciences, The University of Melbourne, Australia., Mumme KD; School of Sport Exercise and Nutrition, Massey University, New Zealand., Conlon CA; School of Sport Exercise and Nutrition, Massey University, New Zealand., von Hurst PR; School of Sport Exercise and Nutrition, Massey University, New Zealand., Haskell-Ramsay CF; Department of Psychology, Northumbria University, United Kingdom., Jones B; Department of Statistics, University of Auckland, New Zealand; The High-Value Nutrition National Science Challenge, New Zealand., Roy NC; The Riddet Institute, New Zealand; The High-Value Nutrition National Science Challenge, New Zealand; Department of Human Nutrition, University of Otago, New Zealand., Coad J; College of Sciences, Massey University, New Zealand., Wall CR; Discipline of Nutrition and Dietetics, University of Auckland, Auckland, New Zealand., Beck KL; School of Sport Exercise and Nutrition, Massey University, New Zealand. Electronic address: k.l.beck@massey.ac.nz.
Jazyk: angličtina
Zdroj: The Journal of nutrition [J Nutr] 2023 Dec; Vol. 153 (12), pp. 3529-3542. Date of Electronic Publication: 2023 Oct 18.
DOI: 10.1016/j.tjnut.2023.10.012
Abstrakt: Background: Vitamin B inadequacies and elevated homocysteine status have been associated with impaired cognitive and cardiometabolic health with aging. There is, however, a scarcity of research investigating integrated profiles of one-carbon (1C) metabolites in this context, including metabolites of interconnected folate, methionine, choline oxidation, and transsulfuration pathways.
Objectives: The study aimed to examine associations between vitamins B and 1C metabolites with cardiometabolic health and cognitive function in healthy older adults, including the interactive effects of Apolipoprotein E-ε4 status.
Methods: Three hundred and thirteen healthy participants (65-74 y, 65% female) were analyzed. Vitamins B were estimated according to dietary intake (4-d food records) and biochemical status (serum folate and vitamin B 12 ). Fasting plasma 1C metabolites were quantified by liquid chromatography with tandem mass spectrometry. Measures of cardiometabolic health included biochemical (lipid panel, blood glucose) and anthropometric markers. Cognitive function was assessed by the Computerized Mental Performance Assessment System (COMPASS) and Montreal Cognitive Assessment (MoCA). Associations were analyzed using multivariate linear (COMPASS, cardiometabolic health) and Poisson (MoCA) regression modeling.
Results: Over 90% of participants met dietary recommendations for riboflavin and vitamins B 6 and B 12 , but only 78% of males and 67% of females achieved adequate folate intakes. Higher serum folate and plasma betaine and glycine concentrations were associated with favorable cardiometabolic markers, whereas higher plasma choline and homocysteine concentrations were associated with greater cardiometabolic risk based on body mass index and serum lipids concentration values (P< 0.05). Vitamins B and homocysteine were not associated with cognitive performance in this cohort, though higher glycine concentrations were associated with better global cognitive performance (P = 0.017), episodic memory (P = 0.016), and spatial memory (P = 0.027) scores. Apolipoprotein E-ε4 status did not modify the relationship between vitamins B or 1C metabolites with cognitive function in linear regression analyses.
Conclusions: Vitamin B and 1C metabolite profiles showed divergent associations with cardiometabolic risk markers and limited associations with cognitive performance in this cohort of healthy older adults.
Competing Interests: Conflict of interest The authors declare they have no conflict of interest.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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