Racial and Ethnic Identity and Vulnerability to Upper Respiratory Viral Infections Among US Children.

Autor:	Bhavnani D; Department of Population Health., Wilkinson M; Department of Pediatrics, Dell Medical School., Chambliss SE; Department of Statistics and Data Sciences, College of Natural Sciences, University of Texas at Austin., Croce EA; Department of Population Health., Rathouz PJ; Department of Population Health., Matsui EC; Department of Population Health.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Mar 14; Vol. 229 (3), pp. 719-727.
DOI:	10.1093/infdis/jiad459
Abstrakt:	Background: It is unclear whether there are racial/ethnic disparities in the risk of upper respiratory viral infection acquisition and/or lower respiratory manifestations. Methods: We studied all children and children with asthma aged 6 to 17 years in the National Health and Nutrition Examination Survey (2007-2012) to evaluate (1) the association between race/ethnicity and upper respiratory infection (URI) and (2) whether race/ethnicity is a risk factor for URI-associated pulmonary eosinophilic inflammation or decreased lung function. Results: Children who identified as Black (adjusted odds ratio [aOR], 1.38; 95% CI, 1.10-1.75) and Mexican American (aOR, 1.50; 95% CI, 1.16-1.94) were more likely to report a URI than those who identified as White. Among those with asthma, Black children were more than twice as likely to report a URI than White children (aOR, 2.28; 95% CI, 1.31-3.95). Associations between URI and pulmonary eosinophilic inflammation or lung function did not differ by race/ethnicity. Conclusions: Findings suggest that there may be racial and ethnic disparities in acquiring a URI but not in the severity of infection. Given that upper respiratory viral infection is tightly linked to asthma exacerbations in children, differences in the risk of infection among children with asthma may contribute to disparities in asthma exacerbations. Competing Interests: Potential conflicts of interest. P. J. R. reported receiving grants or contracts from the National Institutes of Health, State of Texas, and Bass Family Foundation, as well as serving on a data safety monitoring board for Sunovion Pharmaceuticals. E. A. C. reported receiving payment or honoraria from the Pediatric Dermatology Research Alliance and National Eczema Association, as well as serving on a data safety monitoring or advisory board for the National Eczema Association and receiving support for travel from the American Academy of Asthma, Allergy, and Immunology. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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