ATR takes a crack at the nuclear envelope.
| Autor: | Smolka MB; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. Electronic address: mbs266@cornell.edu., Lammerding J; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Molecular cell [Mol Cell] 2023 Oct 19; Vol. 83 (20), pp. 3588-3590. |
| DOI: | 10.1016/j.molcel.2023.09.031 |
| Abstrakt: | In this issue, Joo et al. 1 and Kovacs et al. 2 report that the ATR kinase promotes nuclear envelope rupture through the phosphorylation of Lamin A/C, inducing processes such as cGAS-STING pathway activation, micronuclei clearance, and potentially cell death. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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