Synthesis and evaluation of new magneto-fluorescent carbon dot based on manganese citrate for MRI imaging.

Autor: Ali V; Department of Chemistry, Islamic Azad University, Rasht Branch, Rasht, Iran., Kefayati H; Department of Chemistry, Islamic Azad University, Rasht Branch, Rasht, Iran. shafieeardestani@gmail.com., Shafiee Ardestani M; Faculty of Pharmacy, Department of Radiopharmacy, Tehran University of Medical Sciences, Tehran, Iran., Pourahmad A; Department of Chemistry, Islamic Azad University, Rasht Branch, Rasht, Iran.
Jazyk: angličtina
Zdroj: Magma (New York, N.Y.) [MAGMA] 2024 Feb; Vol. 37 (1), pp. 139-148. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.1007/s10334-023-01117-8
Abstrakt: Objective: Medical imaging techniques have widely revolutionized the diagnosis and treatment of various health conditions. Among these techniques, magnetic resonance imaging (MRI) has stood out as a noninvasive and versatile tool. Now, a breakthrough innovation called "manganese-carbon dots" is poised to enhance MRI imaging and provide physicians with even greater insight into the human body.
Materials and Methods: In this study, one-pot hydrothermal method was used to fabricate magneto-fluorescent carbon quantum dots using manganese citrate, urea, and Mn2+. Manganese citrateAQ3 acted as a carbon source and contrast agent. TEM,XPS, FTIR, UV-Vis, fluorescent analysis confirmed the successful synthesis of magneto-fluorescent carbon quantum dots. The MTT assay was used to study its biocompatiblity, Finallay application of itscompound for mri imaging was investigated.
Results: Characterization Techniques confirmed the succesful synthesis of product. MTT assay showed no toxicity of this product on HEK-293 cells. In addition, it exhibited high r1 relaxivity (7.4 mM-1 S-1) suggesting excellent potential of magneto-fluorescent carbon quantum dots as MRI T1 contrast agent and enabling specific imaging.
Conclusion: Based on the results obtained, the synthesized carbon quantum dots could be used as fluorescence/MRI bimodal platform for in vivo imaging.
(© 2023. The Author(s), under exclusive licence to European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).)
Databáze: MEDLINE
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