Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage.

Autor: Chulanova AA; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia., Smakhtin MY; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. m.yu.smakhtin@mail.ru., Bobyntsev II; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia., Mishina ES; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia., Artyushkova EB; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia., Smakhtina AM; Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Sep; Vol. 175 (5), pp. 700-703. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.1007/s10517-023-05929-5
Abstrakt: We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy. Intragastric administration of carbon tetrachloride for 5 days caused the development of fat degeneration of hepatocytes, a decrease in catalase activity, and an increase in malondialdehyde concentration. Administration of peptides suppressed oxidative peroxidation and stimulated reparative regeneration of hepatocytes; Thymogen analogues produced more pronounced hepatotropic and antioxidant effects than Thymogen. Inclusion of D-Ala enhanced the effect of Thymogen on the processes of regeneration in hepatocytes and the antioxidant effect under conditions of acute carbon tetrachloride hepatopathy. The highest efficiency was achieved when the amino acid was added to the C-end of the molecule.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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