Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions.

Autor: Maksimova AA; Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia. parkinson.dses@gmail.com., Shevela EY; Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia., Tikhonova MA; Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia., Tyrinova TV; Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia., Bogachev SS; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Ostanin AA; Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia., Chernykh ER; Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Sep; Vol. 175 (5), pp. 658-661. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.1007/s10517-023-05921-z
Abstrakt: We studied angiogenin production by human macrophages and evaluated the role of this factor in the macrophage-mediated regulation of fibroblasts. All macrophage subtypes, and especially the efferocytosis-polarized macrophages, M2(LS), actively produced angiogenin. Exogenous recombinant angiogenin dose-dependently enhanced the proliferation and differentiation of dermal fibroblasts. The addition of the angiogenin inhibitor to fibroblasts cultures suppressed the stimulating effect of exogenous angiogenin or M2(LS) conditioned media. These findings indicate the involvement of angiogenin in the macrophage-mediated paracrine regulation of skin fibroblasts.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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