Association of tenofovir diphosphate and lamivudine triphosphate concentrations with HIV and hepatitis B virus viral suppression.

Autor:	Lartey M; Department of Medicine and Therapeutics, University of Ghana Medical School.; Department of Medicine, Korle-Bu Teaching Hospital, Accra, Ghana., Ganu VJ; Department of Medicine, Korle-Bu Teaching Hospital, Accra, Ghana., Tachi K; Department of Medicine and Therapeutics, University of Ghana Medical School.; Department of Medicine, Korle-Bu Teaching Hospital, Accra, Ghana., Yang H; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York., Anderson PL; Colorado Antiviral Pharmacology Laboratory and Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado., Langaee T; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida., Ojewale O; Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA., Boamah I; Department of Microbiology, School of Biomedical and Allied Health Sciences, Accra, Ghana., Obo-Akwa A; Department of Medicine and Therapeutics, University of Ghana Medical School., Antwi K; Department of Medicine, Korle-Bu Teaching Hospital, Accra, Ghana., Bushman LR; Colorado Antiviral Pharmacology Laboratory and Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado., Ellison L; Colorado Antiviral Pharmacology Laboratory and Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado., Kwara A; Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.; Medical Service, North Florida South Georgia Veterans Health System, Gainesville, Florida, USA.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2024 Mar 01; Vol. 38 (3), pp. 351-362. Date of Electronic Publication: 2023 Nov 22.
DOI:	10.1097/QAD.0000000000003764
Abstrakt:	Objective: Concentrations of tenofovir diphosphate (TFV-DP) and lamivudine triphosphate (3TC-TP) in cells are correlates of medication adherence and antiviral activity. However, studies have yet to characterize the simultaneous relationship between TFV-DP and 3TC-TP concentrations with HIV and hepatitis B virus (HBV) suppression. Methods: Individuals with HIV/HBV coinfection on tenofovir disoproxil fumarate (TDF)-containing antiretroviral therapy (ART) were enrolled. Peripheral blood mononuclear cells (PBMCs) and dried blood spots (DBS) samples were collected and steady-state TFV-DP and 3TC-TP concentrations quantified using validated methods. The relationship between patient factors, TFV-DP, and 3TC-TP concentrations in PBMCs and DBS with HBV and HIV viral suppression were examined. Results: Of 138 participants on TDF-containing ART for a median duration (range) of 6 (0.75-15) years, the median age was 43 years and 64% were women. Overall, 128 (92.8%) and 129 (93.5%) had suppressed HIV and HBV viral loads, respectively. Of the 128 participants with suppressed HIV, 122 (95.3%) had suppressed HBV. Self-reported ART adherence, recent change to dolutegravir-based ART, TFV-DP, and 3TC-TP concentrations in PBMCs and DBS were associated with HIV RNA suppression, while HBe antigen positivity, HIV suppression, and TFV-DP concentrations in DBS were associated with HBV DNA suppression (including six persons with HBV nonsuppression and HIV suppression). Conclusion: Long-term TDF/3TC-conatining ART was highly efficacious in individuals with HIV/HBV coinfection. Higher TFV-DP concentrations were predictive of suppression for both viruses. Persistent HBV viremia on TDF/3TC-containg ART requires additional research, but may represent poor adherence and the need for adherence interventions or novel antivirals. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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