The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes.

Autor:	Ullrich S; Biocenter, Ludwig Maximilians University Munich, Munich, Germany., Leidescher S; Biocenter, Ludwig Maximilians University Munich, Munich, Germany., Feodorova Y; Biocenter, Ludwig Maximilians University Munich, Munich, Germany., Thanisch K; Biocenter, Ludwig Maximilians University Munich, Munich, Germany., Fini JB; Département Adaptations du Vivant (AVIV), Physiologie Moléculaire et Adaptation (PhyMA UMR 7221 CNRS), Muséum National d'Histoire Naturelle, CNRS, CP 32, Paris, France., Kaspers B; Department for Veterinary Sciences, Ludwig Maximilians University Munich, Planegg, Germany., Weber F; Department of General, Visceral and Transplantation Surgery, Section of Endocrine Surgery, University Duisburg-Essen, University Hospital Essen, Essen, Germany., Markova B; Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, University Hospital Essen, Essen, Germany., Führer D; Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, University Hospital Essen, Essen, Germany., Romitti M; IRIBHM ULB, Brussels, Belgium., Krebs S; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig Maximilians University Munich, Munich, Germany., Blum H; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig Maximilians University Munich, Munich, Germany., Leonhardt H; Biocenter, Ludwig Maximilians University Munich, Munich, Germany., Costagliola S; IRIBHM ULB, Brussels, Belgium., Heuer H; Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, University Hospital Essen, Essen, Germany., Solovei I; Biocenter, Ludwig Maximilians University Munich, Munich, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Oct 04; Vol. 11, pp. 1265407. Date of Electronic Publication: 2023 Oct 04 (Print Publication: 2023).
DOI:	10.3389/fcell.2023.1265407
Abstrakt:	Abnormalities are indispensable for studying normal biological processes and mechanisms. In the present work, we draw attention to the remarkable phenomenon of a perpetually and robustly upregulated gene, the thyroglobulin gene ( Tg ). The gene is expressed in the thyroid gland and, as it has been recently demonstrated, forms so-called transcription loops, easily observable by light microscopy. Using this feature, we show that Tg is expressed at a high level from the moment a thyroid cell acquires its identity and both alleles remain highly active over the entire life of the cell, i.e., for months or years depending on the species. We demonstrate that this high upregulation is characteristic of thyroglobulin genes in all major vertebrate groups. We provide evidence that Tg is not influenced by the thyroid hormone status, does not oscillate round the clock and is expressed during both the exocrine and endocrine phases of thyrocyte activity. We conclude that the thyroglobulin gene represents a unique and valuable model to study the maintenance of a high transcriptional upregulation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Ullrich, Leidescher, Feodorova, Thanisch, Fini, Kaspers, Weber, Markova, Führer, Romitti, Krebs, Blum, Leonhardt, Costagliola, Heuer and Solovei.)
Databáze:	MEDLINE
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