PolyQ length-based molecular encoding of vocalization frequency in FOXP2.

Autor: Vaglietti S; Rita Levi Montalcini Department of Neuroscience, University of Turin, 10125 Turin, Italy., Villeri V; Rita Levi Montalcini Department of Neuroscience, University of Turin, 10125 Turin, Italy., Dell'Oca M; Rita Levi Montalcini Department of Neuroscience, University of Turin, 10125 Turin, Italy., Marchetti C; Rita Levi Montalcini Department of Neuroscience, University of Turin, 10125 Turin, Italy., Cesano F; Department of Chemistry, University of Turin, 10125 Turin, Italy., Rizzo F; Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR 518057, China., Miller D; Cascades Pika Watch, Oregon Zoo, Portland, OR 97221, USA., LaPierre L; Deptartment of Natural Science, Lower Columbia College, Longview, WA 98632, USA., Pelassa I; Rita Levi Montalcini Department of Neuroscience, University of Turin, 10125 Turin, Italy., Monje FJ; Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria., Colnaghi L; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy., Ghirardi M; Rita Levi Montalcini Department of Neuroscience, University of Turin, 10125 Turin, Italy., Fiumara F; Rita Levi Montalcini Department of Neuroscience, University of Turin, 10125 Turin, Italy.
Jazyk: angličtina
Zdroj: IScience [iScience] 2023 Sep 27; Vol. 26 (10), pp. 108036. Date of Electronic Publication: 2023 Sep 27 (Print Publication: 2023).
DOI: 10.1016/j.isci.2023.108036
Abstrakt: The transcription factor FOXP2, a regulator of vocalization- and speech/language-related phenotypes, contains two long polyQ repeats (Q 1 and Q 2 ) displaying marked, still enigmatic length variation across mammals. We found that the Q 1 /Q 2 length ratio quantitatively encodes vocalization frequency ranges, from the infrasonic to the ultrasonic, displaying striking convergent evolution patterns. Thus, species emitting ultrasonic vocalizations converge with bats in having a low ratio, whereas species vocalizing in the low-frequency/infrasonic range converge with elephants and whales, which have higher ratios. Similar, taxon-specific patterns were observed for the FOXP2-related protein FOXP1. At the molecular level, we observed that the FOXP2 polyQ tracts form coiled coils, assembling into condensates and fibrils, and drive liquid-liquid phase separation (LLPS). By integrating evolutionary and molecular analyses, we found that polyQ length variation related to vocalization frequency impacts FOXP2 structure, LLPS, and transcriptional activity, thus defining a novel form of polyQ length-based molecular encoding of vocalization frequency.
Competing Interests: The authors declare no competing interests.
(© 2023 The Author(s).)
Databáze: MEDLINE
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