Predictors of surgical complications in boys with hypospadias: data from an internationa registry.

Autor:	Scougall K; University of Glasgow, Glasgow, UK., Bryce J; University of Glasgow, Glasgow, UK., Baronio F; IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola, Bologna, Italy., Boal RL; Great North Children's Hospital, Newcastle Upon Tyne, UK., Castera JR; Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Castro S; Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Cheetham T; Great North Children's Hospital, Newcastle Upon Tyne, UK., Costa EC; Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil., Darendeliler F; Istanbul University, Istanbul, Turkey., Davies JH; Southampton Children's Hospital, Southampton, UK., Dirlewanger M; University Hospital of Geneva, Geneva, Switzerland., Gazdagh G; Southampton Children's Hospital, Southampton, UK., Globa E; Ukrainian Research Center of Endocrine Surgery Endocrine Organs and Tissue Transplantation, Kyiv, Ukraine., Guerra-Junior G; State University of Campinas, Campinas, Brazil., Guran T; Marmara University, Istanbul, Turkey., Herrmann G; University Medical Centre, Ulm, Germany., Holterhus PM; University Hospital of Schleswig-Holstein Campus Kiel/Christian-Albrechts-University of Kiel, Kiel, Germany., Akgül AK; Marmara University Faculty of Medicine, Istanbul, Turkey., Markosyan R; Yerevan State Medical University Endocrinology Clinic, Yerevan, Armenia., McElreavey K; Institut Pasteur, Paris, France., Miranda ML; State University of Campinas, Campinas, Brazil., Nordenstrom A; Karolinska University Hospital, Stockholm, Sweden., O'Toole S; Royal Hospital for Children, Glasgow, UK., Poyrazoglu S; Istanbul University, Istanbul, Turkey., Russo G; IRCCS Ospedale San Raffaele, Milano, Italy., Schwitzgebel V; University Hospital of Geneva, Geneva, Switzerland., Stancampiano M; IRCCS Ospedale San Raffaele, Milano, Italy., Steigert M; Graubunden Cantonal Hospital, Chur, Switzerland., Ahmed SF; University of Glasgow, Glasgow, UK., Lucas-Herald AK; University of Glasgow, Glasgow, UK.
Jazyk:	angličtina
Zdroj:	World journal of pediatric surgery [World J Pediatr Surg] 2023 Oct 11; Vol. 6 (4), pp. e000599. Date of Electronic Publication: 2023 Oct 11 (Print Publication: 2023).
DOI:	10.1136/wjps-2023-000599
Abstrakt:	Background: Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence. Methods: Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher's exact tests and spearman's correlation tests were performed on the data to assess associations between clinical factors and complication rates. Results: Of the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications. Conclusions: Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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