Volumetric brain correlates of gait associated with cognitive decline in community-dwelling older adults.

Autor:	Poole VN; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, United States., Oveisgharan S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States., Yu L; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States., Dawe RJ; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.; Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, United States., Leurgans SE; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States.; Department of Family and Preventive Medicine, Rush University Medical Center, Chicago, IL, United States., Zhang S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States., Arfanakis K; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.; Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, United States., Buchman AS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2023 Oct 04; Vol. 15, pp. 1194986. Date of Electronic Publication: 2023 Oct 04 (Print Publication: 2023).
DOI:	10.3389/fnagi.2023.1194986
Abstrakt:	Objective: To determine the extent to which the regional brain volumes associated with slow gait speed can inform subsequent cognitive decline in older adults from the Rush Memory and Aging Project. Approach: We utilized deformation-based morphometry (DBM) in a whole-brain exploratory approach to identify the regional brain volumes associated with gait speed assessed over a short distance during an in-home assessment. We created deformation scores to summarize the gait-associated regions and entered the scores into a series of longitudinal mixed effects models to determine the extent to which deformation predicted change in cognition over time, controlling for associations between gait and cognition. Results: In 438 older adults (81 ± 7; 76% female), DBM revealed that slower gait speed was associated with smaller volumes across frontal white matter, temporal grey matter, and subcortical areas and larger volumes in the ventricles during the same testing cycle. When a subset was followed over multiple (5 ± 2) years, slower gait speed was also associated with annual declines in global cognition, executive functioning, and memory abilities. Several of the gait-related brain structures were associated with these declines in cognition; however, larger ventricles and smaller medial temporal lobe volumes proved most robust and attenuated the association between slow gait and cognitive decline. Conclusion: Regional brain volumes in the ventricles and temporal lobe associated with both slow gait speed and faster cognitive decline have potential to improve risk stratification for cognitive decline in older adults. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Poole, Oveisgharan, Yu, Dawe, Leurgans, Zhang, Arfanakis, Buchman and Bennett.)
Databáze:	MEDLINE
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