Non-invasive temporal interference electrical stimulation of the human hippocampus.

Autor: Violante IR; School of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK. ines.violante@surrey.ac.uk., Alania K; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute, Imperial College London, London, UK., Cassarà AM; Foundation for Research on Information Technologies in Society (IT'IS), Zurich, Switzerland., Neufeld E; Foundation for Research on Information Technologies in Society (IT'IS), Zurich, Switzerland., Acerbo E; Institut de Neurosciences des Systèmes, Aix-Marseille University, INSERM, Marseille, France.; Department of Neurology and Neurosurgery, Emory University Hospital, Atlanta, GA, USA., Carron R; Institut de Neurosciences des Systèmes, Aix-Marseille University, INSERM, Marseille, France.; Department of Functional and Stereotactic Neurosurgery, Timone University Hospital, Marseille, France., Williamson A; Institut de Neurosciences des Systèmes, Aix-Marseille University, INSERM, Marseille, France.; International Clinical Research Center, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Kurtin DL; School of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK., Rhodes E; Department of Brain Sciences, Imperial College London, London, UK.; UK Dementia Research Institute, Imperial College London, London, UK., Hampshire A; Department of Brain Sciences, Imperial College London, London, UK., Kuster N; Foundation for Research on Information Technologies in Society (IT'IS), Zurich, Switzerland.; Department of Information Technology and Electrical Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland., Boyden ES; Departments of Brain and Cognitive Sciences, Media Arts and Sciences, and Biological Engineering, McGovern and Koch Institutes, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Cambridge, MA, USA., Pascual-Leone A; Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Grossman N; Department of Brain Sciences, Imperial College London, London, UK. nirg@imperial.ac.uk.; UK Dementia Research Institute, Imperial College London, London, UK. nirg@imperial.ac.uk.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2023 Nov; Vol. 26 (11), pp. 1994-2004. Date of Electronic Publication: 2023 Oct 19.
DOI: 10.1038/s41593-023-01456-8
Abstrakt: Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain.
(© 2023. The Author(s).)
Databáze: MEDLINE
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