The rat frontal orienting field dynamically encodes value for economic decisions under risk.

Autor: Bao C; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China.; NYU Shanghai, Shanghai, China.; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China.; Sainsbury Wellcome Centre, University College London, London, UK., Zhu X; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China.; NYU Shanghai, Shanghai, China.; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China., Mōller-Mara J; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China.; NYU Shanghai, Shanghai, China.; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China., Li J; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China.; NYU Shanghai, Shanghai, China.; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China.; Sainsbury Wellcome Centre, University College London, London, UK., Dubroqua S; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China.; NYU Shanghai, Shanghai, China.; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China., Erlich JC; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China. j.erlich@ucl.ac.uk.; NYU Shanghai, Shanghai, China. j.erlich@ucl.ac.uk.; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China. j.erlich@ucl.ac.uk.; Sainsbury Wellcome Centre, University College London, London, UK. j.erlich@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2023 Nov; Vol. 26 (11), pp. 1942-1952. Date of Electronic Publication: 2023 Oct 19.
DOI: 10.1038/s41593-023-01461-x
Abstrakt: Frontal and parietal cortex are implicated in economic decision-making, but their causal roles are untested. Here we silenced the frontal orienting field (FOF) and posterior parietal cortex (PPC) while rats chose between a cued lottery and a small stable surebet. PPC inactivations produced minimal short-lived effects. FOF inactivations reliably reduced lottery choices. A mixed-agent model of choice indicated that silencing the FOF caused a change in the curvature of the rats' utility function (U = V ρ ). Consistent with this finding, single-neuron and population analyses of neural activity confirmed that the FOF encodes the lottery value on each trial. A dynamical model, which accounts for electrophysiological and silencing results, suggests that the FOF represents the current lottery value to compare against the remembered surebet value. These results demonstrate that the FOF is a critical node in the neural circuit for the dynamic representation of action values for choice under risk.
(© 2023. The Author(s).)
Databáze: MEDLINE
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