Triggered metabolism of adenosine triphosphate as an explanation for the chemical heterogeneity of heterotopic ossification.

Autor: Sui C; Healthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK., Robinson TE; Healthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK., Williams RL; Healthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK., Eisenstein NM; Healthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK., Grover LM; Healthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK. L.M.Grover@bham.ac.uk.
Jazyk: angličtina
Zdroj: Communications chemistry [Commun Chem] 2023 Oct 19; Vol. 6 (1), pp. 227. Date of Electronic Publication: 2023 Oct 19.
DOI: 10.1038/s42004-023-01015-z
Abstrakt: Heterotopic ossification (HO), the pathological formation of bone in soft tissues, is a debilitating condition, as well as one of the few instances of de novo bone formation in adults. Chemical mapping of HO tissue showed distinct islands of calcium phosphate within phosphate-deficient, calcium-rich regions, suggesting a transition to apatitic bone mineral from a non-phosphatic precursor. The transition of amorphous calcium carbonate (ACC), a generally suggested bone-mineral precursor, in physiological conditions was thus investigated. Here, we show that adenosine triphosphate (ATP), present in high amounts in forming bone, stabilised ACC for weeks in physiological conditions and that enzymatic degradation of ATP triggered rapid crystallisation into apatite, through an amorphous calcium phosphate phase. It is suggested that this localised enzymatic degradation could explain the chemical heterogeneity seen in HO and may also represent a pathway to physiological bone mineralisation.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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