Gender differences in adult atopic dermatitis and clinical implication: Results from a nationwide multicentre study.

Autor: Marani A; Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy., Bianchelli T; Dermatology Unit, Istituto Nazionale, INRCA-IRCCS Hospital, Ancona, Italy., Gesuita R; Centre of Epidemiology and Biostatistics, Polytechnic Marche University, Ancona, Italy., Faragalli A; Centre of Epidemiology and Biostatistics, Polytechnic Marche University, Ancona, Italy., Foti C; Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Bari, Italy., Malara G; Department of Dermatology Grande, Ospedale Metropolitano 'Bianchi Melacrino Morelli', Reggio Calabria, Italy., Micali G; Dermatology Clinic, University of Catania, PO G. Rodolico, AOU Policlinico-Vittorio Emanuele, Catania, Italy., Amerio P; Dermatology Unit, Department of Medicine and Aging Science, University G.D'Annunzio Chieti, Chieti, Italy., Rongioletti F; Università Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Milan, Italy., Corazza M; Dermatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Patrizi A; Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy., Peris K; Fondazione Policlinico Universitario A. Gemelli IRCCS, Dermatologia, Rome, Italy.; Sezione di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Università Cattolica del Sacro Cuore, Rome, Italy.; Oncologia Medica, Università Cattolica del Sacro Cuore, Rome, Italy., Pimpinelli N; Department Health Science Section of Dermatology, University of Florence, Florence, Italy., Parodi A; Dermatology Clinic, Ospedale Policlinico San Martino, Genoa, Italy., Fargnoli MC; Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Cannavo SP; Dermatology Unit, University Hospital Policlinico 'G. Martino', Messina, Italy., Pigatto P; Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy., Pellacani G; Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Ferrucci SM; Department of Physiopathology and Transplantation, Università Degli Studi Di Milano, Milan, Italy.; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Argenziano G; Dermatology Unit, University of Campania, Naples, Italy., Cusano F; Unit of Dermatology, G. Rummo Hospital, Benevento, Italy., Stingeni L; Dermatology Section, Department of Medicine, University of Perugia, Perugia, Italy., Potenza MC; Dermatology Unit, Department of Medico-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome - Polo Pontino, Rome, Italy., Romanelli M; Dermatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Bianchi L; Dermatology Unit, Policlinico Tor Vergata Rome, University of Rome Tor Vergata, Rome, Italy., Offidani A; Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy., Campanati A; Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
Jazyk: angličtina
Zdroj: Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2024 Feb; Vol. 38 (2), pp. 375-383. Date of Electronic Publication: 2023 Dec 13.
DOI: 10.1111/jdv.19580
Abstrakt: Background: Atopic dermatitis (AD) is a common inflammatory skin disease that affects both children and adults. However, limited research has been conducted on gender differences in AD.
Objectives: This study aimed to assess gender differences in adult AD patients, focusing on demographic and clinical features, comorbidities and treatment approaches.
Methods: In this multicentre, observational, cross-sectional study, we enrolled 686 adult patients with AD (357 males and 329 females). For each patient, we collected demographic data (age and sex), anthropometric measurements (weight, height, hip circumference, waist circumference and waist-to-hip ratio), clinical information (onset age, disease duration, severity, itching intensity, impact on quality of life) and noted comorbidities (metabolic, atopic and other). We recorded past and current topical and systemic treatments. We analysed all collected data using statistical techniques appropriate for both quantitative and qualitative variables. Multiple correspondence analysis (MCA) was employed to evaluate the relationships among all clinical characteristics of the patients.
Results: We found no differences in age at onset, disease duration, severity and quality of life impact between males and females. Males exhibited higher rates of hypertriglyceridaemia and hypertension. No significant gender differences were observed in atopic or other comorbidities. Treatment approaches were overlapping, except for greater methotrexate use in males. MCA revealed distinct patterns based on gender, disease severity, age of onset, treatment and quality of life. Adult males with AD had severe disease, extensive treatments and poorer quality of life, while adult females had milder disease, fewer treatments and moderate quality of life impact.
Conclusions: Our study reveals that gender differences in adult AD patients are largely due to inherent population variations rather than disease-related disparities. However, it highlights potential undertreatment of females with moderate AD and quality of life impact, emphasizing the need for equitable AD treatment. JAK inhibitors may offer a solution for gender-based therapeutic parity.
(© 2023 European Academy of Dermatology and Venereology.)
Databáze: MEDLINE
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