Increased perivascular space volume in white matter and basal ganglia is associated with cognition in Parkinson's Disease.

Autor: Donahue EK; Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MCA-243, Los Angeles, CA, 90033, USA., Foreman RP; Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MCA-243, Los Angeles, CA, 90033, USA., Duran JJ; Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MCA-243, Los Angeles, CA, 90033, USA., Jakowec MW; Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MCA-243, Los Angeles, CA, 90033, USA., O'Neill J; Division of Child Psychiatry, UCLA Semel Institute for Neuroscience, Los Angeles, CA, 90024, USA., Petkus AJ; Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MCA-243, Los Angeles, CA, 90033, USA., Holschneider DP; Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MCA-243, Los Angeles, CA, 90033, USA.; Department of Psychiatry & the Behavioral Sciences, University of Southern California, Los Angeles, CA, 90033, USA., Choupan J; Laboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA., Van Horn JD; Department of Psychology, University of Virginia, Charlottesville, VA, 22904, USA.; School of Data Science, University of Virginia, Charlottesville, VA, 22904, USA., Venkadesh S; Department of Psychology, University of Virginia, Charlottesville, VA, 22904, USA., Bayram E; Parkinson and Other Movement Disorder Center, Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA., Litvan I; Parkinson and Other Movement Disorder Center, Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA., Schiehser DM; Veterans Administration San Diego Healthcare System (VASDHS), San Diego, CA, 92161, USA.; Department of Psychiatry, University of California, San Diego, CA, 92093, USA., Petzinger GM; Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MCA-243, Los Angeles, CA, 90033, USA. petzinge@med.usc.edu.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2024 Feb; Vol. 18 (1), pp. 57-65. Date of Electronic Publication: 2023 Oct 19.
DOI: 10.1007/s11682-023-00811-4
Abstrakt: Perivascular spaces (PVS), fluid-filled compartments surrounding brain vasculature, are an essential component of the glymphatic system responsible for transport of waste and nutrients. Glymphatic system impairment may underlie cognitive deficits in Parkinson's disease (PD). Studies have focused on the role of basal ganglia PVS with cognition in PD, but the role of white matter PVS is unknown. This study examined the relationship of white matter and basal ganglia PVS with domain-specific and global cognition in individuals with PD. Fifty individuals with PD underwent 3T T1w magnetic resonance imaging (MRI) to determine PVS volume fraction, defined as PVS volume normalized to total regional volume, within (i) centrum semiovale, (ii) prefrontal white matter (medial orbitofrontal, rostral middle frontal, superior frontal), and (iii) basal ganglia. A neuropsychological battery included assessment of global cognitive function (Montreal Cognitive Assessment, and global cognitive composite score), and cognitive-specific domains (executive function, memory, visuospatial function, attention, and language). Higher white matter rostral middle frontal PVS was associated with lower scores in both global cognitive and visuospatial function. In the basal ganglia higher PVS was associated with lower scores for memory with a trend towards lower global cognitive composite score. While previous reports have shown that greater amount of PVS in the basal ganglia is associated with decline in global cognition in PD, our findings suggest that increased white matter PVS volume may also underlie changes in cognition.
(© 2023. The Author(s).)
Databáze: MEDLINE
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