Risk factors for colorectal cancer in a fecal immunochemical test-positive group: The National Health Insurance Service-National Health Screening Cohort.

Autor: Park JH; Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea., Cho KH; Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea., Choi J; Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea., Chun S; Research Institute, National Health Insurance Service Ilsan Hospital, Goyang, Korea., Lee JK; Research Institute, National Health Insurance Service Ilsan Hospital, Goyang, Korea., Cho H; Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea., Kim B; Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Jazyk: angličtina
Zdroj: Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2024 Jan; Vol. 39 (1), pp. 74-80. Date of Electronic Publication: 2023 Oct 19.
DOI: 10.1111/jgh.16374
Abstrakt: Background and Aim: Colorectal cancer (CRC) was the fourth most common cancer in Republic of Korea in 2019. It has a gradually increasing mortality rate, indicating the importance of screening for CRC. Among the various CRC screening test, fecal immunochemical test (FIT) is a simple yet most commonly used. Neverthelss, there have been only few long-term studies on subjects with FIT-positive. Therefore, in this study, we aimed to investigate the risk factors for CRC in FIT-positive patients using the National Health Insurance Service Bigdata database.
Methods: Among 1 737 633 individuals with a FIT screening result for CRC in 2009, 101 143 (5.82%) were confirmed to be FIT positive. The CRC incidence over 10 years (up to 2018) of these participants was investigated using the National Cancer Registry.
Results: Out of the 101 143 FIT-positive participants, 4395 (4.35%) were diagnosed with CRC. The FIT-positive patients who underwent a second round of screening showed a 5-year cumulative CRC incidence of approximately 1.25%, whereas those who did not showed an incidence of approximately 3.75%. Among the FIT-positive patients, the CRC incidence in the non-compliance group for the second round of screening was 2.8 times higher than that in the compliance group.
Conclusions: In FIT-positive participants, non-compliance with the second round of screening was identified as a major risk factor for CRC development. It is necessary to establish appropriate strategies for managing risk factors for CRC in FIT-positive patients to increase the rate of compliance with the second round of CRC screening.
(© 2023 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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