The role of adiposity, adipokines and polymorphisms of leptin and adiponectin in myelodysplastic syndromes.

Autor: Aguiar APN; Cancer Cytogenomic Laboratory, Federal University of Ceará, Fortaleza, CE60430-275, Brazil.; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Mendonça PDS; Cancer Cytogenomic Laboratory, Federal University of Ceará, Fortaleza, CE60430-275, Brazil.; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil.; University Hospital Walter Cantidio, Brazilian Company of Hospital Services (EBSERH), Fortaleza, CE, Brazil., Lima Junior RCP; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil.; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil., Mota AGM; Cancer Cytogenomic Laboratory, Federal University of Ceará, Fortaleza, CE60430-275, Brazil.; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Wong DVT; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil.; Department of Pathology and Forensic Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Oliveira RTG; Cancer Cytogenomic Laboratory, Federal University of Ceará, Fortaleza, CE60430-275, Brazil.; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Ribeiro-Júnior HL; Cancer Cytogenomic Laboratory, Federal University of Ceará, Fortaleza, CE60430-275, Brazil.; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Pinheiro RF; Cancer Cytogenomic Laboratory, Federal University of Ceará, Fortaleza, CE60430-275, Brazil.; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil.; Post-Graduate Program of Pathology, Federal University of Ceará, Fortaleza, CE, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.; Post-graduate Program in Medical Science, Federal University of Ceará, Fortaleza, CE, Brazil., Magalhães SMM; Cancer Cytogenomic Laboratory, Federal University of Ceará, Fortaleza, CE60430-275, Brazil.; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.; Post-graduate Program in Medical Science, Federal University of Ceará, Fortaleza, CE, Brazil.
Jazyk: angličtina
Zdroj: The British journal of nutrition [Br J Nutr] 2024 Mar 14; Vol. 131 (5), pp. 737-748. Date of Electronic Publication: 2023 Oct 19.
DOI: 10.1017/S0007114523002283
Abstrakt: The aim of the present study was to investigate the relationship between leptin and adiponectin gene polymorphisms, circulating levels of leptin and adiponectin, adiposity and clinical markers in patients with myelodysplastic syndrome (MDS). This cross-sectional study was conducted with 102 adults and elderly MDS patients and 102 age- and sex-matched controls. Clinical characteristics, co-morbidities, anthropometric data, laboratory evaluation and genetic analysis (polymorphisms -2548G > A/rs7799039 of the LEP gene and +276G > T/rs1501299 of the ADIPOQ gene) were investigated. Serum leptin was higher and adiponectin lower in MDS when compared with controls. There was a significant positive correlation between serum leptin levels and BMI ( r = 0·264, P = 0·025), waist circumference ( r = 0·235, P = 0·047), body fat percentage (BF %) ( r = 0·373, P = 0·001) and the fat mass index (FMI) ( r = 0·371, P < 0·001). A lower mean adiponectin was found among patients with high BF %, higher visceral adiposity index and metabolic syndrome. A significant association was found between the AA genotype (mutant) of the LEP polymorphism rs7799039 and male sex and blast excess (≥ 5 %). In addition, a significant association was observed between the TT genotype (mutant) of the ADIPOQ rs1501299 polymorphism and Fe overload. These results demonstrate the importance of a comprehensive and systematic evaluation in patients with MDS in order to identify and control negative factors not related to the disease at an early stage.
Databáze: MEDLINE
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