Dehydroepiandrosterone mediates associations between trauma-related symptoms and anterior pituitary volume in children and adolescents.

Autor: Picci G; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, Nebraska, USA.; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, Nebraska, USA., Casagrande CC; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, Nebraska, USA., Ott LR; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, Nebraska, USA., Petro NM; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, Nebraska, USA., Christopher-Hayes NJ; Center for Mind and Brain, University of California Davis, Davis, California, USA., Johnson HJ; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, Nebraska, USA., Willett MP; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, Nebraska, USA., Okelberry HJ; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, Nebraska, USA., Wang YP; Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana, USA., Stephen JM; Mind Research Network, Albuquerque, New Mexico, USA., Calhoun VD; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of technology, and Emory University, Atlanta, Georgia, USA., Wilson TW; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, Nebraska, USA.; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, Nebraska, USA.; Department of Pharmacology & Neuroscience, Creighton University, Omaha, Nebraska, USA.
Jazyk: angličtina
Zdroj: Human brain mapping [Hum Brain Mapp] 2023 Dec 15; Vol. 44 (18), pp. 6388-6398. Date of Electronic Publication: 2023 Oct 18.
DOI: 10.1002/hbm.26516
Abstrakt: Introduction: The anterior pituitary gland (PG) is a potential locus of hypothalamic-pituitary-adrenal (HPA) axis responsivity to early life stress, with documented associations between dehydroepiandrosterone (DHEA) levels and anterior PG volumes. In adults, elevated anxiety/depressive symptoms are related to diminished DHEA levels, and studies have shown a positive relationship between DHEA and anterior pituitary volumes. However, specific links between responses to stress, DHEA levels, and anterior pituitary volume have not been established in developmental samples.
Methods: High-resolution T1-weighted MRI scans were collected from 137 healthy youth (9-17 years; M age  = 12.99 (SD = 1.87); 49% female; 85% White, 4% Indigenous, 1% Asian, 4% Black, 4% multiracial, 2% not reported). The anterior and posterior PGs were manually traced by trained raters. We examined the mediating effects of salivary DHEA on trauma-related symptoms (i.e., anxiety, depression, and posttraumatic) and PG volumes as well as an alternative model examining mediating effects of PG volume on DHEA and trauma-related symptoms.
Results: DHEA mediated the association between anxiety symptoms and anterior PG volume. Specifically, higher anxiety symptoms related to lower DHEA levels, which in turn were related to smaller anterior PG.
Conclusions: These results shed light on the neurobiological sequelae of elevated anxiety in youth and are consistent with adult findings showing suppressed levels of DHEA in those with greater comorbid anxiety and depression. Specifically, adolescents with greater subclinical anxiety may exhibit diminished levels of DHEA during the pubertal window, which may be associated with disruptions in anterior PG growth.
(© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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