Association of Smoke and Nicotine Product Consumption With Sensorineural Hearing Loss: A Population-Level Analysis.

Autor:	Li M; Sidney Kimmel Medical College, Thomas Jefferson University., Perlov NM; Sidney Kimmel Medical College, Thomas Jefferson University., Patel J; Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia Pennsylvania., Amin D; Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia Pennsylvania., Kumar A; Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia Pennsylvania., Urdang ZD; Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia Pennsylvania., Willcox TO; Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia Pennsylvania., Chiffer RC; Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia Pennsylvania.
Jazyk:	angličtina
Zdroj:	Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [Otol Neurotol] 2023 Dec 01; Vol. 44 (10), pp. 1094-1099. Date of Electronic Publication: 2023 Oct 19.
DOI:	10.1097/MAO.0000000000004031
Abstrakt:	Objective: To test the hypothesis that use of cigarettes or other products with either cigarette-like smoke profile or high nicotine content by young populations increases the odds of developing sensorineural hearing loss (SNHL). Study Design: Retrospective cohort study. Setting: TriNetX US Collaborative Network (2003-2022). Patients: Approximately 3.6 million patients at least 18 years old. Intervention: None. Main Outcome Measures: The primary outcome of interest was diagnosis of SNHL, defined using medical billing codes ( International Classification of Diseases, Tenth Revision , Current Procedural Terminology , etc.). Cohort inclusion criteria included electronic health record entry after 2003, age 18 to 54 or 55+ years at index, and status of cigarette, noncigarette nicotine, or cannabis use. Covariates were controlled via 1:1 propensity score matching for SNHL-related conditions, including diabetes mellitus and ischemic diseases. Odds for developing SNHL were calculated against control subjects aged 18 to 54 years who have no record of nicotine/cannabis use. Results: Odds for developing SNHL are higher for people 18 to 54 years old who use any nicotine product (odds ratio [95% confidence interval], 5.91 [5.71-6.13]), cigarettes only (4.00 [3.69-4.33]), chewing tobacco only (9.04 [7.09-11.63]), or cannabis only (3.99 [3.60-4.44]) compared with control. People 55+ years old who use no products also showed increased odds for SNHL (4.73 [4.63-4.85]). Conclusions: Both nicotine and smoke exposure seem to be strongly associated with increased odds for developing SNHL, with chewing tobacco having the strongest association. Competing Interests: Sources of support and disclosure of funding: Z.D.U. was supported by National Institutes of Health institutional training grant T32GM008562. The remaining authors disclose no conflicts of interest. (Copyright © 2023, Otology & Neurotology, Inc.)
Databáze:	MEDLINE
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