Dissociation of Centrally and Peripherally Induced Transcranial Magnetic Stimulation Effects in Nonhuman Primates.

Autor:	Perera ND; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455., Alekseichuk I; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455., Shirinpour S; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455., Wischnewski M; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455., Linn G; Translational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, NYU Grossman School of Medicine, New York, New York 10016., Masiello K; Translational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Butler B; Translational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Russ BE; Translational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Schroeder CE; Translational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032.; Department of Neurosurgery, The Neurological Institute of New York, Columbia University Irving Medical Center, New York, New York 10032., Falchier A; Translational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, NYU Grossman School of Medicine, New York, New York 10016., Opitz A; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455 aopitz@umn.edu.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2023 Dec 13; Vol. 43 (50), pp. 8649-8662. Date of Electronic Publication: 2023 Dec 13.
DOI:	10.1523/JNEUROSCI.1016-23.2023
Abstrakt:	Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation method that is rapidly growing in popularity for studying causal brain-behavior relationships. However, its dose-dependent centrally induced neural mechanisms and peripherally induced sensory costimulation effects remain debated. Understanding how TMS stimulation parameters affect brain responses is vital for the rational design of TMS protocols. Studying these mechanisms in humans is challenging because of the limited spatiotemporal resolution of available noninvasive neuroimaging methods. Here, we leverage invasive recordings of local field potentials in a male and a female nonhuman primate (rhesus macaque) to study TMS mesoscale responses. We demonstrate that early TMS-evoked potentials show a sigmoidal dose-response curve with stimulation intensity. We further show that stimulation responses are spatially specific. We use several control conditions to dissociate centrally induced neural responses from auditory and somatosensory coactivation. These results provide crucial evidence regarding TMS neural effects at the brain circuit level. Our findings are highly relevant for interpreting human TMS studies and biomarker developments for TMS target engagement in clinical applications. SIGNIFICANCE STATEMENT Transcranial magnetic stimulation (TMS) is a widely used noninvasive brain stimulation method to stimulate the human brain. To advance its utility for clinical applications, a clear understanding of its underlying physiological mechanisms is crucial. Here, we perform invasive electrophysiological recordings in the nonhuman primate brain during TMS, achieving a spatiotemporal precision not available in human EEG experiments. We find that evoked potentials are dose dependent and spatially specific, and can be separated from peripheral stimulation effects. This means that TMS-evoked responses can indicate a direct physiological stimulation response. Our work has important implications for the interpretation of human TMS-EEG recordings and biomarker development. (Copyright © 2023 the authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu