Endoscopic sleeve gastroplasty as an early tool against obesity: a multicenter international study on an overweight population.

Autor: Brunaldi VO; Gastroenterology and Hepatology Division, Mayo Clinic, Rochester, Minnesota, USA., Galvao Neto M; Mohak Bariatric and Robotic Center, Indore, India; Elias Ortiz & Company, Tijuana, Mexico; Endovitta Institute, São Paulo, Brazil., Sharaiha RZ; Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York, USA., Hoff AC; Angioskope GI, São José dos Campos, Brazil., Bhandari M; Mohak Bariatric and Robotic Center, Indore, India., McGowan C; True You Weight Loss, Cary, North Carolina, USA., Ujiki MB; Department of Surgery, University of Chicago, Pritzker School of Medicine, Chicago, Illinois, USA., Kedia P; Methodist Dallas Medical Center, Dallas, Texas, USA., Ortiz E; Elias Ortiz & Company, Tijuana, Mexico., VanderWel B; Eviva, Shoreline, Washington, USA., Abu Dayyeh BK; Gastroenterology and Hepatology Division, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: abudayyeh.barham@mayo.edu.
Jazyk: angličtina
Zdroj: Gastrointestinal endoscopy [Gastrointest Endosc] 2024 Mar; Vol. 99 (3), pp. 371-376. Date of Electronic Publication: 2023 Oct 16.
DOI: 10.1016/j.gie.2023.10.033
Abstrakt: Background and Aims: Endoscopic sleeve gastroplasty (ESG) is an effective, minimally invasive gastric remodeling procedure to treat mild and moderate obesity. Early adoption of ESG may be desirable to try to halt progression of obesity, but there are few data on its efficacy and safety for overweight patients.
Methods: This was a multicenter, international, analytical case series. Six U.S., 1 Brazilian, 1 Mexican, and 1 Indian center were included. Overweight patients according to local practice undergoing ESG were considered eligible for the study. The end points were percent total weight loss (%TWL), body mass index (BMI) reduction, rate of BMI normalization, and rate of adverse events.
Results: One hundred eighty-nine patients with a mean age of 42.6 ± 14.1 years and a mean BMI of 27.79 ± 1.17 kg/m 2 were included. All procedures were successfully accomplished, and there were 3 intraprocedural adverse events (1.5%). The mean %TWL was 12.28% ± 3.21%, 15.03% ± 5.30%, 15.27% ± 5.28%, and 14.91% ± 5.62% at 6, 12, 24, and 36 months, respectively. At 12 and 24 months, 76% and 86% of patients achieved normal BMI, with a mean BMI reduction of 4.13 ± 1.46 kg/m 2 and 4.25 ± 1.58 kg/m 2 . There was no difference in mean %TWL in the first quartile versus the fourth quartile of BMI in any of the time points. However, the BMI normalization rate was statistically higher in the first group at 6 and 12 months (6 months, 100% vs 48.5% [P < .01]; 12 months, 86.2% vs 50% [P < .01]; 24 months, 84.6% vs 76.1% [P = .47]; 36 months, 86.3% vs 66.6% [P = .26]).
Conclusions: ESG is safe and effective in treating overweight patients with high BMI normalization rates. It could help halt or delay the progression to obesity.
Competing Interests: Disclosure The following authors disclosed financial relationships: A. C. Hoff: consultant for Apollo Endosurgery. P. Kedia: consultant for Boston Scientific, Medtronic, and Olympus. R. Z. Sharaiha: consultant for Boston Scientific, Cook Medical, and Lumendi. M. Bhandari: consultant for Intuitive, Ethicon, and Allurion. B. VanderWel: consultant for Apollo Endosurgery. M. G. Neto: consultant for Apollo Endosurgery, GI Dynamics, and Keyron. M. B. Ujiki: board member for Boston Scientific; paid consultant for Olympus and Cook; and receives payment for lectures from Medtronic, Gore, and Erbe. C. McGowan: consultant for Boston Scientific. B. K. A. Dayehh: consultant for DyaMx, Boston Scientific, USGI Medical, and Endo-TAGSS; research support from Boston Scientific, USGI Medical, Apollo Endosurgery, Spatz Medical, GI Dynamics, Cairn Diagnostics, Aspire Bariatrics, and Medtronic; and speaker for Johnson & Johnson, EndoGastric Solutions, and Olympus. All other authors disclosed no financial relationships.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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