ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells.

Autor:	Lafita-Navarro MC; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hao YH; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Jiang C; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Jang S; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Chang TC; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Brown IN; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Venkateswaran N; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Maurais E; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Stachera W; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Zhang Y; Quantitative Biomedical Research Center, Department of Population & Data Sciences, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mundy D; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Live Cell Imaging Core Facility, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Han J; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Tran VM; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mettlen M; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Xu L; Quantitative Biomedical Research Center, Department of Population & Data Sciences, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Woodruff JB; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Grishin NV; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Kinch L; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mendell JT; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Buszczak M; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Conacci-Sorrell M; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: maralice.conaccisorrell@utsouthwestern.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2023 Oct 31; Vol. 42 (10), pp. 113280. Date of Electronic Publication: 2023 Oct 16.
DOI:	10.1016/j.celrep.2023.113280
Abstrakt:	Increased nucleolar size and activity correlate with aberrant ribosome biogenesis and enhanced translation in cancer cells. One of the first and rate-limiting steps in translation is the interaction of the 40S small ribosome subunit with mRNAs. Here, we report the identification of the zinc finger protein 692 (ZNF692), a MYC-induced nucleolar scaffold that coordinates the final steps in the biogenesis of the small ribosome subunit. ZNF692 forms a hub containing the exosome complex and ribosome biogenesis factors specialized in the final steps of 18S rRNA processing and 40S ribosome maturation in the granular component of the nucleolus. Highly proliferative cells are more reliant on ZNF692 than normal cells; thus, we conclude that effective production of small ribosome subunits is critical for translation efficiency in cancer cells. Competing Interests: Declaration of interests The authors declare no competing interest. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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