Impact of race and ethnicity on outcomes after autologous stem cell transplantation for patients with newly diagnosed multiple myeloma.

Autor: Davis JA; Division of Malignant Hematology and Bone Marrow Transplant, Department of Pharmacy, Medical University of South Carolina, 86 Jonathan Lucas St, Charleston, SC, 29425, USA. Davisjaa@musc.edu., Thurlapati A; Department of Hematology and Bone Marrow Transplant, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA., Weeda E; Medical University of South Carolina College of Pharmacy, Charleston, SC, USA., Gaffney KJ; Division of Malignant Hematology and Bone Marrow Transplant, Department of Pharmacy, Medical University of South Carolina, 86 Jonathan Lucas St, Charleston, SC, 29425, USA., Smith D; Division of Malignant Hematology and Bone Marrow Transplant, Department of Pharmacy, Medical University of South Carolina, 86 Jonathan Lucas St, Charleston, SC, 29425, USA., Maldonado A; Division of Malignant Hematology and Bone Marrow Transplant, Department of Pharmacy, Medical University of South Carolina, 86 Jonathan Lucas St, Charleston, SC, 29425, USA., Granger K; Division of Malignant Hematology and Bone Marrow Transplant, Department of Pharmacy, Medical University of South Carolina, 86 Jonathan Lucas St, Charleston, SC, 29425, USA., Martin KE; Department of Hematology and Bone Marrow Transplant, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA., Williams YM; Department of Hematology and Bone Marrow Transplant, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA., Herrington T; Medical University of South Carolina College of Pharmacy, Charleston, SC, USA., Velayati A; Department of Hematology and Bone Marrow Transplant, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA., Bakos JK; Department of Hematology and Bone Marrow Transplant, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA., Green K; Department of Hematology and Bone Marrow Transplant, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA., Hashmi H; Department of Hematology and Bone Marrow Transplant, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA.
Jazyk: angličtina
Zdroj: Annals of hematology [Ann Hematol] 2024 Jan; Vol. 103 (1), pp. 251-258. Date of Electronic Publication: 2023 Oct 18.
DOI: 10.1007/s00277-023-05503-z
Abstrakt: Non-Hispanic Black patients are disproportionally affected by multiple myeloma (MM) and whether efficacy outcomes after autologous stem cell transplant (ASCT) differ by race and ethnicity remains an area of active investigation. This study included 449 patients enriched with a large proportion of non-Hispanic Black patients and sought to highlight the impact of race and ethnicity on outcomes after HDT-ASCT for patients with newly diagnosed MM. We found induction chemotherapy followed by high-dose therapy-ASCT and maintenance chemotherapy is associated with long-term PFS and OS, regardless of race or ethnicity.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: