Applications of nanomaterials in anti-VEGF treatment for ophthalmic diseases.

Autor: Teng L; The First Bethune Hospital of Jilin University, Jilin, China., Sun Y; The First Bethune Hospital of Jilin University, Jilin, China., Teng S; The First Bethune Hospital of Jilin University, Jilin, China., Hui P; The First Bethune Hospital of Jilin University, Jilin, China.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2024 Feb; Vol. 112 (2), pp. 296-306. Date of Electronic Publication: 2023 Oct 18.
DOI: 10.1002/jbm.a.37626
Abstrakt: Angiogenesis has been determined to be essential in the occurrence and metastasis of diabetic retinopathy (DR), age-related macular degeneration (AMD), retinal vein occlusion (RVO), choroidal neovascularization (CNV), retinopathy of prematurity (ROP), tumor, etc. However, the clinical use of anti-vascular endothelial growth factors (VEGF) drugs is currently limited due to its high cost, potential side effects, and need for repeated injections. In recent years, nanotechnology has shown promising results in inhibiting neovascularization and reducing reactive oxygen species (ROS) or inflammatory factors. Some nanomaterials can also act as vehicles for drug delivery, such as lipid nanoparticles and PLGA. The process of angiogenesis and its molecular mechanism are discussed in this article. At the same time, this study aims to systematically review the research progress of nanotechnology and offer more treatment options for neovascularization-related diseases in clinical ophthalmology.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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