Enaminone-directed ruthenium(II)-catalyzed C-H activation and annulation of arenes with diazonaphthoquinones for polycyclic benzocoumarins.
| Autor: | Mondal S; Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, Tamil Nadu, India. mbaidya@iitm.ac.in., Giri CK; Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, Tamil Nadu, India. mbaidya@iitm.ac.in., Baidya M; Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, Tamil Nadu, India. mbaidya@iitm.ac.in. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Nov 02; Vol. 59 (88), pp. 13187-13190. Date of Electronic Publication: 2023 Nov 02. |
| DOI: | 10.1039/d3cc03999d |
| Abstrakt: | The weakly coordinating enaminone functionality has been leveraged for a C-H bond activation strategy under ruthenium catalysis and employed in the regioselective annulative coupling of arenes with diazonaphthoquinones, offering polycyclic benzocoumarins in very high yields. The enaminone motif plays a dual role and the protocol operates through a Ru(II)/Ru(IV) catalytic pathway which is amenable to the diversification of various pharmacophore-coupled substrates. |
| Databáze: | MEDLINE |
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