Adverse childhood experiences and psychological functioning among women with schizophrenia or bipolar disorder: population-based study.

Autor:	Köhler-Forsberg O; Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Denmark; and Department of Clinical Medicine, Aarhus University, Denmark., Ge F; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Iceland., Hauksdóttir A; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Iceland., Thordardottir EB; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Iceland; and Mental Health Services, Landspitali, The National University Hospital of Iceland, Iceland., Ásbjörnsdóttir K; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Iceland., Rúnarsdóttir H; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Iceland., Tómasson G; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Iceland., Jakobsdóttir J; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Iceland., Guðmundsdóttir B; Faculty of Medicine, University of Iceland, Iceland; and Mental Health Services, Landspitali, The National University Hospital of Iceland, Iceland., Björnsson AS; Faculty of Psychology, University of Iceland, Iceland., Sigurðsson E; Faculty of Medicine, University of Iceland, Iceland., Aspelund T; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Iceland., Valdimarsdottir UA; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Iceland; Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Sweden; and Harvard T.H. Chan School of Public Health, USA.
Jazyk:	angličtina
Zdroj:	The British journal of psychiatry : the journal of mental science [Br J Psychiatry] 2024 Jan; Vol. 224 (1), pp. 6-12.
DOI:	10.1192/bjp.2023.128
Abstrakt:	Background: Adverse childhood experiences (ACEs) are well-known risk factors for schizophrenia and bipolar disorder. Aims: The aim was to study the associations between specific ACEs and psychological functioning in women with schizophrenia or bipolar disorder. Method: Among 29 367 women (mean age 44 years) from the Icelandic Stress-And-Gene-Analysis (SAGA) study, 534 (1.8%, mean age 40) reported having been diagnosed with schizophrenia or bipolar disorder, which were combined to 'severe mental disorders'. Participants reported on 13 types of ACEs, childhood deprivation and psychological functioning (defined as coping ability and current symptoms of depression, anxiety and sleep disturbances). Adjusted Poisson regression calculated prevalence ratios (PRs) between ACEs and severe mental disorders. Linear regression assessed the association between ACEs and psychological functioning among women with a severe mental disorder. Results: Women with a severe mental disorder reported more ACEs (mean 4.57, s.d. = 2.82) than women without (mean 2.51, s.d. = 2.34) in a dose-dependent manner (fully-adjusted PR = 1.23 per ACE, 95% CI 1.20-1.27). After mutual adjustment for other ACEs, emotional abuse, sexual abuse, mental illness of a household member, emotional neglect, bullying and collective violence were associated with severe mental disorders. Among women with severe mental disorders, a higher number of ACEs was associated with increased symptom burden of depression (β = 2.79, 95% CI = 1.19-4.38) and anxiety (β = 2.04, 95% CI = 0.99-3.09) including poorer sleep quality (β = 0.83, 95% CI = 0.07-1.59). Findings were similar for schizophrenia and bipolar disorder separately. Conclusion: Women with schizophrenia or bipolar disorder show a strong history of ACEs, which may interfere with their psychological functioning and, therefore, need to be addressed as part of their treatment, for example, with trauma-focused psychotherapy.
Databáze:	MEDLINE
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