Associations of C-reactive protein with depressive symptoms over time after mild to moderate ischemic stroke in the PROSCIS-B cohort.

Autor: Schaeff VLK; Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany. Viktoria.schaeff@charite.de., Sperber PS; Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany.; German Centre for Cardiovascular Research DZHK, Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, Department of Neurology With Experimental Neurology, Berlin, Germany.; Charité-Universitätsmedizin Berlin, Experimental and Clinical Research Center, Berlin, Germany., Piper SK; Charité-Universitätsmedizin Berlin, Institute of Biometry and Clinical Epidemiology, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; Charité-Universitätsmedizin Berlin, Institute of Medical Informatics, Berlin, Germany., Giesers NK; Department of Neurology, Carl Von Ossietzky University, Oldenburg, Germany., Gertz K; Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany.; German Centre for Cardiovascular Research DZHK, Berlin, Berlin, Germany., Heuschmann PU; Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.; Clinical Trial Center Würzburg, University Hospital Würzburg, Würzburg, Germany.; Institute for Medical Data Science, University Hospital Würzburg, Würzburg, Germany., Endres M; Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany.; German Centre for Cardiovascular Research DZHK, Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; German Center for Neurodegenerative Disease DZNE, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Neurocure Cluster of Excellence, Berlin, Germany., Liman TG; Charité-Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany.; German Centre for Cardiovascular Research DZHK, Berlin, Berlin, Germany.; Department of Neurology, Carl Von Ossietzky University, Oldenburg, Germany.; German Center for Neurodegenerative Disease DZNE, Berlin, Germany.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2024 Feb; Vol. 271 (2), pp. 909-917. Date of Electronic Publication: 2023 Oct 18.
DOI: 10.1007/s00415-023-12038-w
Abstrakt: Background and Purpose: C-reactive protein serves as a marker of inflammation and is linked to depression in the general population. We aimed to assess whether elevated baseline levels of high-sensitivity C-reactive protein (hs-CRP) are associated with depressive symptoms over time in a prospective cohort of mild-to-moderate first-ever ischemic stroke patients.
Methods: Data were obtained from the Prospective Cohort with Incident Stroke Berlin (NCT01363856). Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) at three annual follow-up points. We assessed the association of elevated levels of hs-CRP with CES-D scores over time via linear mixed models. In a subgroup analysis, we explored an interaction effect with sex.
Results: We included 585 ischemic stroke patients with baseline data on CRP levels. The mean age was 67 (13 SD), 39% (n = 226) were female, and the median National Institutes of Health Stroke Scale (NIHSS) was 3 (IQR 1-4). Twenty percent of survivors showed evidence for depressive symptoms one year after stroke with CES-D ≥ 16, 21% at year two, and 17% at year three. Higher log-transformed baseline hs-CRP levels were associated with higher CES-D Scores over time in the adjusted linear mixed model (β = 1.28; (95% CI 0.22-2.34)). The subgroup analysis revealed an interaction effect of hs-CRP on depressive symptoms in women (β = 2.33; (95% CI 0.71-3.95)).
Conclusion: In our cohort with mild-to-moderate first-ever ischemic stroke patients, hs-CRP levels were associated with more depressive symptoms over time, with an interaction effect for the female sex.
Study Registration: https://clinicaltrials.gov ; Unique identifier: NCT01363856.
(© 2023. The Author(s).)
Databáze: MEDLINE
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