The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes.

Autor: Bond DM; Department of Anatomy, University of Otago, Dunedin, New Zealand., Ortega-Recalde O; Department of Anatomy, University of Otago, Dunedin, New Zealand., Laird MK; Department of Anatomy, University of Otago, Dunedin, New Zealand., Hayakawa T; Faculty of Environmental Earth Science, Hokkaido University, Sapporo, Hokkaido, 060-0808, Japan., Richardson KS; Department of Anatomy, University of Otago, Dunedin, New Zealand.; Biology Department, University of Montana Western, Dillon, MT, 59725, USA., Reese FCB; Department of Anatomy, University of Otago, Dunedin, New Zealand., Kyle B; Department of Anatomy, University of Otago, Dunedin, New Zealand., McIsaac-Williams BE; Department of Anatomy, University of Otago, Dunedin, New Zealand., Robertson BC; Department of Zoology, University of Otago, Dunedin, New Zealand., van Heezik Y; Department of Zoology, University of Otago, Dunedin, New Zealand., Adams AL; Department of Zoology, University of Otago, Dunedin, New Zealand., Chang WS; School of Life and Environmental Science, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Health and Biosecurity, CSIRO, Canberra, ACT, Australia., Haase B; Vertebrate Genome Laboratory, The Rockefeller University, New York, NY, USA., Mountcastle J; Vertebrate Genome Laboratory, The Rockefeller University, New York, NY, USA., Driller M; Leibniz Institute for Zoo and Wildlife Research, Berlin, DE, Germany., Collins J; Tree of Life, Wellcome Sanger Institute, Hinxton, Cambridge, UK., Howe K; Tree of Life, Wellcome Sanger Institute, Hinxton, Cambridge, UK., Go Y; Graduate School of Information Science, Hyogo University, Hyogo, Japan.; Cognitive Genomics Research Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Aichi, Japan.; Department of System Neuroscience, National Institute for Physiological Sciences, Aichi, Japan., Thibaud-Nissen F; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Lister NC; School of Biotechnology and Biomolecular Science, Faculty of Science, UNSW Sydney, Sydney, NSW, 2052, Australia., Waters PD; School of Biotechnology and Biomolecular Science, Faculty of Science, UNSW Sydney, Sydney, NSW, 2052, Australia., Fedrigo O; Vertebrate Genome Laboratory, The Rockefeller University, New York, NY, USA., Jarvis ED; Vertebrate Genome Laboratory, The Rockefeller University, New York, NY, USA.; Laboratory of Neurogenetics of Language, The Rockefeller University, New York, NY, 10065, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA., Gemmell NJ; Department of Anatomy, University of Otago, Dunedin, New Zealand., Alexander A; Department of Anatomy, University of Otago, Dunedin, New Zealand., Hore TA; Department of Anatomy, University of Otago, Dunedin, New Zealand. tim.hore@otago.ac.nz.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Oct 17; Vol. 14 (1), pp. 6364. Date of Electronic Publication: 2023 Oct 17.
DOI: 10.1038/s41467-023-41784-8
Abstrakt: Combining genome assembly with population and functional genomics can provide valuable insights to development and evolution, as well as tools for species management. Here, we present a chromosome-level genome assembly of the common brushtail possum (Trichosurus vulpecula), a model marsupial threatened in parts of their native range in Australia, but also a major introduced pest in New Zealand. Functional genomics reveals post-natal activation of chemosensory and metabolic genes, reflecting unique adaptations to altricial birth and delayed weaning, a hallmark of marsupial development. Nuclear and mitochondrial analyses trace New Zealand possums to distinct Australian subspecies, which have subsequently hybridised. This admixture allowed phasing of parental alleles genome-wide, ultimately revealing at least four genes with imprinted, parent-specific expression not yet detected in other species (MLH1, EPM2AIP1, UBP1 and GPX7). We find that reprogramming of possum germline imprints, and the wider epigenome, is similar to eutherian mammals except onset occurs after birth. Together, this work is useful for genetic-based control and conservation of possums, and contributes to understanding of the evolution of novel mammalian epigenetic traits.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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