Rostral Anterior Cingulate Cortex Oscillatory Power Indexes Treatment-Resistance to Multiple Therapies in Major Depressive Disorder.

Autor:	Prentice A; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands, a.prentice@maastrichtuniversity.nl.; Research Institute Brainclinics, Brainclinics Foundation, Nijmegen, The Netherlands, a.prentice@maastrichtuniversity.nl.; Synaeda Research, Synaeda Psycho Medisch Centrum, Drachten, The Netherlands, a.prentice@maastrichtuniversity.nl., Barreiros AR; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Brain Dynamics Centre, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia., van der Vinne N; Research Institute Brainclinics, Brainclinics Foundation, Nijmegen, The Netherlands.; Synaeda Research, Synaeda Psycho Medisch Centrum, Drachten, The Netherlands., Stuiver S; Department of Psychiatry, Rijnstate Depression Centre, Arnhem, The Netherlands.; Technical Medical Centre, University of Twente, Enschede, The Netherlands., van Dijk H; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Research Institute Brainclinics, Brainclinics Foundation, Nijmegen, The Netherlands., van Waarde JA; Department of Psychiatry, Rijnstate Depression Centre, Arnhem, The Netherlands., Korgaonkar M; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Brain Dynamics Centre, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia., Sack AT; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands., Arns M; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Research Institute Brainclinics, Brainclinics Foundation, Nijmegen, The Netherlands.
Jazyk:	angličtina
Zdroj:	Neuropsychobiology [Neuropsychobiology] 2023; Vol. 82 (6), pp. 373-383. Date of Electronic Publication: 2023 Oct 17.
DOI:	10.1159/000533853
Abstrakt:	Introduction: High rostral anterior cingulate cortex (rACC) activity is proposed as a nonspecific prognostic marker for treatment response in major depressive disorder, independent of treatment modality. However, other studies report a negative association between baseline high rACC activation and treatment response. Interestingly, these contradictory findings were also found when focusing on oscillatory markers, specifically rACC-theta power. An explanation could be that rACC-theta activity dynamically changes according to number of previous treatment attempts and thus is mediated by level of treatment-resistance. Methods: Primarily, we analyzed differences in rACC- and frontal-theta activity in large national cross-sectional samples representing various levels of treatment-resistance and resistance to multimodal treatments in depressed patients (psychotherapy [n = 175], antidepressant medication [AD; n = 106], repetitive transcranial magnetic stimulation [rTMS; n = 196], and electroconvulsive therapy [ECT; n = 41]), and the respective difference between remitters and non-remitters. For exploratory purposes, we also investigated other frequency bands (delta, alpha, beta, gamma). Results: rACC-theta activity was higher (p < 0.001) in the more resistant rTMS and ECT patients relative to the less resistant psychotherapy and AD patients (psychotherapy-rTMS: d = 0.315; AD-rTMS: d = 0.320; psychotherapy-ECT: d = 1.031; AD-ECT: d = 1.034), with no difference between psychotherapy and AD patients. This association was even more pronounced after controlling for frontal-theta. Post hoc analyses also yielded effects for delta, beta, and gamma bands. Conclusion: Our findings suggest that by factoring in degree of treatment-resistance during interpretation of the rACC-theta biomarker, its usefulness in treatment selection and prognosis could potentially be improved substantially in future real-world practice. Future research should however also investigate specificity of the theta band. (© 2023 The Author(s). Published by S. Karger AG, Basel.)
Databáze:	MEDLINE
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