BIN1 in the Pursuit of Ousting the Alzheimer's Reign: Impact on Amyloid and Tau Neuropathology.

Autor: Kaur I; College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Behl T; School of Health Sciences and Technology, University of Petroleum and Energy Studies, Bidholi, Dehradun, India. tapanbehl31@gmail.com., Sundararajan G; Department of Pharmaceutics, Faculty of Pharmacy, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India., Panneerselvam P; Faculty of Pharmacy, Sree Balaji Medical College and Hospital Campus, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India., Vijayakumar AR; Faculty of Pharmacy, Sree Balaji Medical College and Hospital Campus, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India., Senthilkumar GP; Faculty of Pharmacy, Sree Balaji Medical College and Hospital Campus, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India., Venkatachalam T; Department of Pharmaceutical Chemistry, JKKMMRFs-Amnai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam, Tamil Nadu, India., Jaglan D; Faculty of Pharmaceutical Sciences, DAV University, Jalandhar, Punjab, India., Yadav S; School of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Chhatrapti Shahu Ji Maharaj University, Uttar Pradesh, Kanpur, India., Anwer K; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia., Fuloria NK; Faculty of Pharmacy, AIMST University, Bedong, Kedah, Malaysia.; Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Saveetha University, Chennai, Tamil Nadu, India., Sehgal A; GHG Khalsa College of Pharmacy, Gurusar Sadhar, Punjab, India., Gulati M; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 1444411, India.; Faculty of Health, ARCCIM, University of Technology Sydney, Ultimo, NSW, 20227, Australia., Chigurupati S; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, 52571, Kingdom of Saudi Arabia. S.Chigurupati@qu.edu.sa.; Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Saveetha Nagar, Thandalam, Chennai, Tamilnadu, 602105, India. S.Chigurupati@qu.edu.sa.
Jazyk: angličtina
Zdroj: Neurotoxicity research [Neurotox Res] 2023 Dec; Vol. 41 (6), pp. 698-707. Date of Electronic Publication: 2023 Oct 17.
DOI: 10.1007/s12640-023-00670-3
Abstrakt: Alzheimer's disease contributes to 60-70% of all dementia cases in the general population. Belonging to the BIN1/amphiphysin/RVS167 (BAR) superfamily, the bridging integrator (BIN1) has been identified to impact two major pathological hallmarks in Alzheimer's disease (AD), i.e., amyloid beta (Aβ) and tau accumulation. Aβ accumulation is found to increase by BIN1 knockdown in cortical neurons in late-onset AD, due to BACE1 accumulation at enlarged early endosomes. Two BIN1 mutants, KR and PL, were identified to exhibit Aβ accumulation. Furthermore, BIN1 deficiency by BIN1-related polymorphisms impairs the interaction with tau, thus elevating tau phosphorylation, altering synapse structure and tau function. Even though the precise role of BIN1 in the neuronal tissue needs further investigation, the authors aim to throw light on the potential of BIN1 and unfold its implications on tau and Aβ pathology, to aid AD researchers across the globe to examine BIN1, as an appropriate target gene for disease management.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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