| Autor: |
May GB; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., de Souza BR; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., Gueuvoghlanian-Silva BY; Innovation Department, Hospital Israelita Albert Einstein, São Paulo, SP, 05652-900, Brazil., Dos Reis EC; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., Mostardeiro SR; Universidade do Sul de Santa Catarina (UNISUL)-Campus Pedra Branca, Palhoça, SC, 88137-270, Brazil., Boabaid May PP; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., Mateo EC; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., Vietta GG; Universidade do Sul de Santa Catarina (UNISUL)-Campus Pedra Branca, Palhoça, SC, 88137-270, Brazil., Hoss GW; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil. |
| Abstrakt: |
Purpose: This work was designed to identify the pharmacogenetic profile of Brazilian psychiatric patients receiving psychoactive drug treatment according to ethnicity. Methods: Based on the GnTech ® database, this cross-sectional study analyzed data from self-reported sociodemographic and genetic results from the next-generation sequencing panel composed of 26 pharmacogenes from 359 psychotropic drug users. Results: Variant frequencies of multiple pharmacogenes presented differences between ethnicities ( CYP3A5 , CYP2D6 , CYP1A2 , CYP2B6 , CYP3A4 , UGT1A4 , UGT2B15 , ABCB1 rs1045642 , ADRA2A rs1800544 , COMT rs4680 , GRIK4 rs1954787 , GSK3B rs334558 , GSK3B rs6438552 , HTR1A rs6295 , HTR2A rs7997012 , HTR2C rs1414334 , MTHFR rs1801131 , OPRM1 rs1799971 and 5-HTTLPR ), endorsing the necessity of individual-level analyses in drug treatment. Conclusion: A discussion of pharmacogenomic test implementation in psychiatric clinical practice is needed to improve treatment choices, especially in Brazil, a multiethnic country. |
