Alteration of the immunophenotype and cytokine profiles in patients affected by neuroendocrine neoplasms.

Autor: Boemi I; Laboratory of Cellular and Molecular Endocrinology, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy., Piccini S; Endocrinology, Diabetology, and Andrology Unit, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy., Colombo FS; Flow Cytometry Core, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy., Smiroldo V; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy., Zerbi A; Department of Biomedical Sciences, Humanitas University, 20072, Pieve Emanuele, Italy.; Pancreas Surgery Unit, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy., Capretti G; Department of Biomedical Sciences, Humanitas University, 20072, Pieve Emanuele, Italy.; Pancreas Surgery Unit, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy., Alloisio M; Department of Biomedical Sciences, Humanitas University, 20072, Pieve Emanuele, Italy.; Thoracic Surgery Unit, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy., Trivellin G; Laboratory of Cellular and Molecular Endocrinology, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, 20072, Pieve Emanuele, Italy., Lavezzi E; Endocrinology, Diabetology, and Andrology Unit, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy., Mazziotti G; Endocrinology, Diabetology, and Andrology Unit, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, 20072, Pieve Emanuele, Italy., Vitali E; Laboratory of Cellular and Molecular Endocrinology, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy. eleonora.vitali@humanitasresearch.it., Lania AG; Endocrinology, Diabetology, and Andrology Unit, IRCCS Humanitas Research Hospital, 20089, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, 20072, Pieve Emanuele, Italy.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2024 Mar; Vol. 83 (3), pp. 810-823. Date of Electronic Publication: 2023 Oct 16.
DOI: 10.1007/s12020-023-03563-9
Abstrakt: Purpose: Neuroendocrine neoplasms (NENs) are tumors that arise from cells of the endocrine system and are most common in the gastrointestinal tract, the pancreas, and the lungs. Their incidence is rapidly increasing and the therapeutic options available are limited.
Methods: Since the immune system can interfere with tumor growth and response to therapy, using flow cytometry we investigated the immunophenotype in samples of peripheral blood leukocytes from patients with pancreatic (Pan-NENs) and pulmonary NENs (Lung-NENs). Moreover, we performed a multiplex analysis of 13 key cytokines and growth factors essential for the immune response in the plasma of NEN patients and controls.
Results: Patients presented with a higher percentage of granulocytes, a lower percentage of lymphocytes, and an increase in the granulocytes to lymphocytes ratio compared to healthy donors. These alterations were more marked in patients with metastasis. Somatostatin analogs (SSAs) restored the immunophenotype of patients to that seen in healthy donors. Finally, Pan-NEN patients showed a higher plasma concentration of IP-10, MCP-1, and IL-8 compared to healthy donors, suggesting a potential role for these cytokines as diagnostic biomarkers.
Conclusion: This study highlighted differences in the immunophenotype of patients with Pan- and Lung-NENs compared to healthy individuals; these alterations were partially restored by therapy.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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