Changes of Arterial and Venous Cerebral Blood Flow Correlation in Moderate-to-Severe Traumatic Brain Injury: A CT Perfusion Study.

Autor:	Trofimov AO; Department of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia., Agarkova DI; Department of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia., Trofimova KA; Department of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia., Lidji-Goryaev KV; Department of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia., Nemoto E; Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA., Bragina OA; Lovelace Biomedical Research Institute, Albuquerque, NM, USA., Bragin DE; Lovelace Biomedical Research Institute, Albuquerque, NM, USA.; Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Jazyk:	angličtina
Zdroj:	Advances in experimental medicine and biology [Adv Exp Med Biol] 2023; Vol. 1438, pp. 51-58.
DOI:	10.1007/978-3-031-42003-0_9
Abstrakt:	We compared differences in perfusion computed tomography (PCT)-derived arterial and venous cerebral blood flow (CBF) in moderate-to-severe traumatic brain injury (TBI) as an indication of changes in cerebral venous outflow patterns referenced to arterial inflow. Moderate-to-severe TBI patients (women 53; men 74) underwent PCT and were stratified into 3 groups: I (moderate TBI), II (diffuse severe TBI without surgery), and III (diffuse severe TBI after the surgery). Arterial and venous CBF was measured by PCT in both the middle cerebral arteries (CBFmca) and the upper sagittal sinus (CBFuss). In group I, CBFmca on the left and right sides were significantly correlated with each other (p < 0.0001) and with CBFuss (p = 0.048). In group II, CBFmca on the left and right sides were also correlated (p < 0.0000001) but not with CBFuss. Intracranial pressure reactivity (PRx) and CBFuss were correlated (p = 0.00014). In group III, CBFmca on the side of the removed hematoma was not significantly different from the opposite CBFmca (p = 0.680) and was not correlated with CBFuss. Conclusions: The increasing severity of TBI is accompanied by an impairment of the correlation between the arterial and venous CBF in the supratentorial vessels suggesting shifting in arterial and venous CBF in severe TBI associated with increased ICP reflected by PRx. (© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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