The interplay of obesity, microbiome dynamics, and innovative anti-obesity strategies in the context of endometrial cancer progression and therapeutic approaches.

Autor: Burkett WC; University of North Carolina at Chapel Hill, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, United States of America. Electronic address: wesley.burkett@unchealth.unc.edu., Clontz AD; University of North Carolina at Chapel Hill, Nutrition Research Institute, United States of America. Electronic address: adclontz@email.unc.edu., Keku TO; University of North Carolina at Chapel Hill, Department of Medicine, Center for Gastrointestinal Biology and Disease, United States of America. Electronic address: temitope_keku@med.unc.edu., Bae-Jump V; University of North Carolina at Chapel Hill, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, United States of America; University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, United States of America. Electronic address: victoria_baejump@med.unc.edu.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2023 Nov; Vol. 1878 (6), pp. 189000. Date of Electronic Publication: 2023 Oct 14.
DOI: 10.1016/j.bbcan.2023.189000
Abstrakt: Endometrial cancer (EC) is the most common gynecologic malignancy in the United States, and its incidence and mortality are rising. Obesity is more tightly associated with EC than any other cancer. Thus, the rising prevalence of obesity and associated risk factors, including diabetes and insulin resistance, cause alarm. The metabolic derangements of obesity increase the bioavailability of estrogen, hyperinsulinemia, and inflammation in a complex system with direct and indirect effects on the endometrium, resulting in proliferation and, ultimately, carcinogenesis. In addition, the gut dysbiosis associated with obesity helps contribute to these metabolic derangements, priming an individual for developing EC and perhaps affecting treatment efficacy. More recent studies are beginning to explore obesity's effect on the local tumor microbiome of EC and its role in carcinogenesis. Significant and sustained weight loss in individuals can considerably decrease the risk of EC, likely through reversal of the altered metabolism and dysbiosis resulting obesity. Bariatric surgery is the gold standard for successful weight loss and highlights how reversing of the systemic effects of obesity can reduce EC risk. However, the current limited availability, knowledge, and imposed stigma of bariatric surgery prohibits population-level reductions in EC. Therefore, effective and maintainable non-surgical dietary and pharmacologic interventions are needed.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Victoria Bae-Jump reports a relationship with Merck & Co Inc. that includes: funding grants. Victoria Bae-Jump reports a relationship with Chimerix Inc. that includes: funding grants. Victoria Bae-Jump reports a relationship with Genentech Inc. that includes: funding grants.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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