The Transplant Bellwether: Endothelial Cells in Antibody-Mediated Rejection.
| Autor: | Franco-Acevedo A; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA., Pathoulas CL; Center for Vascular Biology, University of Connecticut Medical School, Farmington, CT., Murphy PA; Center for Vascular Biology, University of Connecticut Medical School, Farmington, CT., Valenzuela NM; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2023 Nov 01; Vol. 211 (9), pp. 1276-1285. |
| DOI: | 10.4049/jimmunol.2300363 |
| Abstrakt: | Ab-mediated rejection of organ transplants remains a stubborn, frequent problem affecting patient quality of life, graft function, and grant survival, and for which few efficacious therapies currently exist. Although the field has gained considerable knowledge over the last two decades on how anti-HLA Abs cause acute tissue injury and promote inflammation, there has been a gap in linking these effects with the chronic inflammation, vascular remodeling, and persistent alloimmunity that leads to deterioration of graft function over the long term. This review will discuss new data emerging over the last 5 y that provide clues into how ongoing Ab-endothelial cell interactions may shape vascular fate and propagate alloimmunity in organ transplants. (Copyright © 2023 by The American Association of Immunologists, Inc.) |
| Databáze: | MEDLINE |
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